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The Effect of Physiotherapy Integrated With Yoga and Mindfulness on Individuals With Fibromyalgia

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Editor's note
Fibromyalgia's hallmark is a nervous system stuck in overdrive—and this emerging trial tests whether combining body-based therapy with parasympathetic retraining can downshift it measurably. The evidence landscape remains fragmented on multimodal interventions; this RCT's rigor on autonomic markers and disability will help clarify whether the benefit is real or ritual. Rheumatologists, pain specialists, and physiotherapists managing treatment-resistant FM should watch for these results.

Source: ctgov · University Hospital Tuebingen · ACTIVE_NOT_RECRUITING · 2026-05-26

URL: https://clinicaltrials.gov/study/NCT07145788

AI rationale (4/5, tier: emerging): RCT measuring autonomic nervous system function (HRV proxy) and stress biomarkers in chronic condition; vagal/HPA targets via mindfulness/yoga with physiological outcomes.

The current study investigates the effect of an integrative physiotherapy and mind-body program called PhYoMind intervention on disability and symptoms in individuals with fibromyalgia (FM). Participants will be randomized to either the PhYoMind intervention, which combines specific physiotherapy techniques with yoga and mindfulness, or to a home exercise control group. The intervention lasts 8 weeks, with supervised and home sessions. The primary outcome is disability, with secondary outcomes including measures of central and autonomic nervous system function, pain perception, stress, fatigue, and sleep quality. Adverse events and adherence of the intervention will be also assessed.

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Published 2026-05-28 · Last kit-update 2026-05-28