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All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.

Topic
Autophagy & cellular renewal 16Chronic inflammation 5Microbiome ecology 21Mitochondrial biology 22Mucosa 55Resolution biology 4Sleep biology 18Stress biology 15
Evidence tier
Evidence 3Hypothesis 65Speculation 30
Study type
Human observational 1Mixed 2Animal 1Mechanism review 17
Tags
mechanism 19barrier 17microbiome 14inflammation 14marker 14intervention 6supplement 6technique 3resolution 2ernæring 2omega-3 2goblet cells 2dysbiosis 2sepsis 2eicosanoids 1

156 articles of 156

Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming
Sleep biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42199420/) **Authors:** Cain J, Hurrell BP, Shen S, Speliakos P, Akbari O **Venue:** Front Immunol · 2026 **AI relevance (4…
Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity
Sleep biology · Discovery ·
**Source:** [ctgov](https://clinicaltrials.gov/study/NCT07589647) **Authors:** First Affiliated Hospital of Zhejiang University **Venue:** RECRUITING · 2026-05-27 **Abstract** …
Influence of Intermittent Hypoxia on Loop Gain in Healthy Subjects
Sleep biology · Discovery ·
**Source:** [ctgov](https://clinicaltrials.gov/study/NCT07409649) **Authors:** Poitiers University Hospital **Venue:** NOT_YET_RECRUITING · 2026-05-27 **Abstract** Sleep apnoe…
<scp>METTL14</scp> Regulates Adipose Tissue Macrophage Polarization via <scp>JAK2</scp> / <scp>STAT3</scp> Pathway to Attenuate Obstructive Sleep Apnea‐Related Systemic Inflammation
Sleep biology · Discovery ·
**Source:** [openalex](https://doi.org/10.1096/fj.202600889r) **Authors:** Yu Zhang, Zhe Zhao, Chaojie Li, Xiaojing Sun, Ruixiang Guo **Venue:** The FASEB Journal · 2026-05-26 …
Effects of chronic jetlag on high-fat and high-fructose diet induced renal injury in mice
Sleep biology · Discovery ·
**Source:** [openalex](https://doi.org/10.1038/s41598-026-54538-5) **Authors:** Lin Xing, Junyan Xie, Ying Shi, Ruoyi Zheng, Tao Zhang **Venue:** Scientific Reports · 2026-05-26 …
Association between allostatic load and risk of breast carcinoma in situ in the UK biobank
Stress biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42201432/) **Authors:** Fengfu C, Hua X, Chen X, Liu M, Chen A **Venue:** Cancer Causes Control · 2026 May 27 **AI relevanc…
Exposure to Endocrine Disruptors and Stress Hormones Across Pregnancy Trimesters: Links with Maternal Telomere Length
Stress biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42201077/) **Authors:** Vakonaki E, Hatzidaki E, Baliou S, Marmara M, Alegakis A **Venue:** J Xenobiot · 2026 May 7 **AI re…
Characterization of Isoorientin and Paeoniflorin as Botanical Glucocorticoid Receptor Modulators from White Peony and Chasteberry
Stress biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42196951/) **Authors:** Bashatwah RM, Jesikiewicz LT, Hardy AL, Villegas JA, Li K **Venue:** Nutrients · 2026 May 7 **AI re…
Relative Leukocyte Telomere Length Is Associated with Multimorbidity Burden in Older Adults: Evidence for Sex-Specific Associations
Stress biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42196441/) **Authors:** La Grotta R, Crocco P, Leonova A, Dato S, Passarino G **Venue:** Int J Mol Sci · 2026 May 16 **AI r…
Effect of a Sequence of Specific Manual Therapy Techniques Targeting the Autonomic Nervous System in Healthy Adults
Stress biology · Discovery ·
**Source:** [ctgov](https://clinicaltrials.gov/study/NCT06477822) **Authors:** Universitat Internacional de Catalunya **Venue:** COMPLETED · 2026-05-27 **Abstract** The activi…
Effect of Hot Spring Therapy on Autonomic Nervous System and Exercise Performance During Altitude Training
Stress biology · Discovery ·
**Source:** [ctgov](https://clinicaltrials.gov/study/NCT07608887) **Authors:** Macao Polytechnic University **Venue:** RECRUITING · 2026-05-27 **Abstract** This randomized con…
Stress during the first 1,000 days of life in humans, when everything begins
Stress biology · Discovery ·
**Source:** [europepmc](https://europepmc.org/article/PMC/PMC13201393) **Authors:** Vitalis T, Verney C. **Venue:** Frontiers in human neuroscience · 2026-05-27 **AI relevance …
PRRSV NSP2 hijacks host lipophagy via a LIPE-PNPLA2-AMPK-MTOR axis to promote viral replication
Autophagy & cellular renewal · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42200529/) **Authors:** Zhu Z, Lin Q, Zhang X, Zhang M, Yan Y **Venue:** Autophagy · 2026 May 27 **AI relevance (4/5):** Di…
Corrigendum to “Lithium ameliorates spinal cord injury through endoplasmic reticulum stress-regulated autophagy and alleviated apoptosis through IRE1 and PERK/eIF2α signaling pathways” [J Neurorestoratol 11 (2023) 100081]
Autophagy & cellular renewal · Discovery ·
**Source:** [openalex](https://doi.org/10.1016/j.jnrt.2026.100291) **Authors:** Fang Wang, Chengyi Zhang, Qiongchi Zhang, Jiaxi Li, Yuewen Xue **Venue:** Journal of Neurorestorat…
FOXO transcription factors in Alzheimer’s Disease: balancing neuroprotection and neuronal degeneration
Autophagy & cellular renewal · Discovery ·
**Source:** [openalex](https://doi.org/10.1007/s11033-026-12021-4) **Authors:** Mukul Shyam, Aleen Veronica, Jyoti Wadhwa, Vidhi Sharma, Oveyaa B M **Venue:** Molecular Biology R…
The Mechanistic Crosstalk between Probiotics, ncRNAs, and Autophagy: Implications for Colorectal Cancer Precision Medicine
Autophagy & cellular renewal · Discovery ·
**Source:** [openalex](https://doi.org/10.1017/erm.2026.10053) **Authors:** Nayeralsadat Fatemi, Ali Mohammad Alizadeh, Zahra Sadeghloo, Amir Sadeghi **Venue:** Expert Reviews in…
Mechanism of Inonotus hispidus in suppressing renal cell carcinoma proliferation via regulation of the PI3K/AKT/mTOR pathway
Autophagy & cellular renewal · Discovery ·
**Source:** [europepmc](https://europepmc.org/article/PMC/PMC13201449) **Authors:** Wei Y, Liu H, Wang A, Huang Q, Liu R, Yu H, Song Y, Hu R, Li X. **Venue:** Frontiers in pharma…
Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer’s Disease: Mechanisms and Therapeutic Restoration
Mitochondrial biology · Discovery ·
**Source:** [openalex](https://doi.org/10.1007/s12031-026-02531-y) **Authors:** Ahmed M Abdelaziz, Mustafa M Shokr, Mohamed K. Fathy, Mohamed N Fawzy **Venue:** Journal of Molecu…
Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Naïve Alzheimer's disease
Sleep biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42184681/) **Authors:** Zheng W, Zhou Y, Xia Y, Wang Y **Venue:** J Prev Alzheimers Dis · 2026 May 25 **AI relevance (5/5):…
Transglutaminase and its role in Alzheimer's disease: focus on mitochondria, aging, defective mitophagy, synaptic degeneration, and metabolomics
Mitochondrial biology · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42185591/) **Authors:** Hiruthyaswamy SP, Rao D, Balakrishna S, Macarius NMN, Sakthivel YK, Deepankumar K, Vijayan M. **Ve…
Anti-inflammatory effects of oral NLRP3 inhibition with ruvonoflast among individuals at elevated cardiovascular risk
Chronic inflammation · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42187339/) **Authors:** Ray KK, Clarke N, Thornton P, Miles AE, Digby Z, Davies MJ, Gorman M, Mullen B, Reader V, Magill M,…
The CLOCK-BMAL1 complex in circadian regulation: structure, mechanisms, and therapeutic targeting
Sleep biology · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42189225/) **Authors:** Kamel EM, Khadrawy SM, Allam AA, Ahmed NA, Alkhayl FFA, Lamsabhi AM. **Venue:** Inflammation resea…
Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Naïve Alzheimer's disease
Sleep biology · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42184681/) **Authors:** Zheng W, Zhou Y, Xia Y, Wang Y. **Venue:** The journal of prevention of Alzheimer's disease · 2026…
Corrigendum to "JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy" [J Orthop Transl 51 (2025) 132-144 / doi: 10.1016/j.jot.2025.01.001]
Mitochondrial biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42199805/) **Authors:** Xie Y, Lv Z, Li W, Lin J, Sun W **Venue:** J Orthop Translat · 2026 Jul **AI relevance (5/5):** Dir…
Mitochondrial transfer: A comprehensive analysis of mechanistic insights, preclinical applications, and technological innovations
Mitochondrial biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42199126/) **Authors:** Wang Y, Wang Z, Zhao J, Zhou Y, Wei D **Venue:** Neural Regen Res · 2026 May 14 **AI relevance (5/5…
Sleep and Performance
Sleep biology · Discovery ·
**Source:** [ctgov](https://clinicaltrials.gov/study/NCT07608614) **Authors:** University of Washington **Venue:** RECRUITING · 2026-05-27 **Abstract** This research is being …
LEF1 gene mutation impairs the intestinal barrier and causes diarrhea
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42176141/) **Authors:** Jie J, Qiu M, Liu X, Zhang Q, Xie J **Venue:** Mol Cell Pediatr · 2026 May 23 **AI relevance (5/5):…
Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin-Active Carbohydrate Sulfatases
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42175861/) **Authors:** Tomlinson CWE, Bergers MD, Bolam DN, Luis AS, Cartmell A **Venue:** Angew Chem Int Ed Engl · 2026 May…
Faecalibacterium prausnitzii-derived extracellular vesicles ameliorate experimental colitis through regulating barrier immunity and gut microbiota
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42173875/) **Authors:** Nie X, Li Q, Tao Z, Xu Y, Li B **Venue:** NPJ Sci Food · 2026 May 23 **AI relevance (5/5):** F. pra…
Phellinus linteus polysaccharides alleviate DSS-induced colitis in mice by restoring gut microbiota homeostasis, preserving intestinal barrier integrity, and attenuating JAK2/STAT3-associated inflammatory signaling
Mucosa · Discovery ·
**Source:** [biorxiv](https://doi.org/10.21203/rs.3.rs-9420434/v1) **Authors:** Xu L, Yang Y, Shi C, Li G **Venue:** bioRxiv (preprint) · **AI relevance (5/5):** Directly addr…
Effect of Oral Calcium Butyrate Supplementation in Obesity
Mucosa · Discovery ·
**Source:** [ctgov](https://clinicaltrials.gov/study/NCT07583017) **Authors:** Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran **Venue:** NOT_YET_RECRUITING ·…
Polysaccharide from Atractylodes macrocephala Koidz. protects against avian pathogenic Escherichia coli-induced intestinal barrier Dysfunction via Suppressing PI3K/Akt-Mediated Claudin-2 upregulation
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42184735/) **Authors:** Chen S, Qu X, Wu J **Venue:** Poult Sci · 2026 May 15 **AI relevance (5/5):** Directly addresses in…
Dietary dimethylglycine alleviates cyclic heat stress-induced jejunal injury in yellow-feathered broilers by inhibiting the TLR4/NF-κB signaling pathway and restoring MUC2 expression
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42184641/) **Authors:** Shao D, Hu L, Guo W, Chen J, Guo X **Venue:** Poult Sci · 2026 May 21 **AI relevance (5/5):** Direc…
Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42177552/) **Authors:** Zou F, Wu Z, Wang S, Xu M, Xia P, Hu Y, Fang T, Hu P, Huang C, Deng F. **Venue:** Journal of trans…
Personalized barrier recovery induced by Lactobacillus helveticus SBT2171 in an In Vitro model of ulcerative colitis-derived fecal supernatants
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42177520/) **Authors:** Khademi M, Kazemifard N, Fathi M, Farmani M, Baradaran Ghavami S, Khanabadi B, Shahrokh S. **Venue…
Rapid early life colonization of the intestinal tract by Akkermansia muciniphila after voluntary feeding
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42177437/) **Authors:** Dumlao JM, McCallum P, Hodak CR, Guinto E, Enns W, Davey LE, Choy JC. **Venue:** BMC microbiology …
LEF1 gene mutation impairs the intestinal barrier and causes diarrhea
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42176141/) **Authors:** Jie J, Qiu M, Liu X, Zhang Q, Xie J, Geng L, Gong S, Cheng Y. **Venue:** Molecular and cellular pe…
Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin-Active Carbohydrate Sulfatases
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42175861/) **Authors:** Tomlinson CWE, Bergers MD, Bolam DN, Luis AS, Cartmell A, Armstrong Z. **Venue:** Angewandte Chemi…
Faecalibacterium prausnitzii-derived extracellular vesicles ameliorate experimental colitis through regulating barrier immunity and gut microbiota
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42173875/) **Authors:** Nie X, Li Q, Tao Z, Xu Y, Li B, Xie J, Nie S. **Venue:** NPJ science of food · 2026-05-23 **Abst…
Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis
Speculation
Chronic inflammation · Discovery ·
**Source:** openalex · Origin: **JP** · J LI, Terukazu Sanui, Miyu Shida, Karen Yotsumoto, Mwannes Ahmad · Frontiers in Immunology · 2026-05-26 **URL:** https://doi.org/10…
Effect of methotrexate on endothelial function in psoriasis patients
Speculation
Chronic inflammation · Discovery ·
**Source:** openalex · Origin: **BR** · Tiago Almeida Santos Costa, Isabella Bonilha, Sheila Tatsumi Kimura Medorima, Thiago Quinaglia Araújo Costa Silva, Simon · Journal of …
Dexmedetomidine attenuates LPS-induced acute lung injury via activation of mitochondrial autophagy
Speculation
Mitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Huaixin Xing, Yan Ma, Xiangzhen Min, Yingui Sun, Guanrong Li · European journal of medical research · 2026-05-26 **URL:** https://d…
Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging mice
Speculation
Mitochondrial biology · Discovery ·
**Source:** openalex · Origin: **FR** · Márcio A. C. Ribeiro, Vanessa Morais Lima, Thiago N. Menezes, Wenjin Yang, Juliane C. Campos · bioRxiv (Cold Spring Harbor Laboratory)…
Fecal Microbiota Transplant for Anorexia Nervosa
Speculation
Microbiome ecology · Discovery ·
**Source:** ctgov · Hamilton Health Sciences Corporation · NOT_YET_RECRUITING · 2026-05-27 **URL:** https://clinicaltrials.gov/study/NCT06593366 **AI rationale (4/5, tier: …
Anti-inflammatory and gut microbiota-modulating effects of a novel mannan from Scilla scilloides on DSS-induced colitis in mice
Speculation
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Yuanhao Qiu, Zihan Liu, Weishuang Tong, Weiwei Fan, Aoying Zhang · Journal of Functional Foods · 2026-05-26 **URL:** https://doi.or…
Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages
Speculation
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Shenghao Xv, Jie Hao, Sanhua Deng, Zhengyin Zhang, Runshu Wang · Frontiers in Immunology · 2026-05-26 **URL:** https://doi.org/10.3…
Eubacterium rectale Mitigates Inflammatory Bowel Disease via Modulation of Glutamine Metabolism Through the GLS2 and NF-κB Pathway
Speculation
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Lu Han, Yiyi Jin, Wen Lin, Zide Liu, Chunyan Zeng · npj Science of Food · 2026-05-26 **URL:** https://doi.org/10.1038/s41538-026-00…
Low-dimensional population dynamics in the brainstem gate REM sleep
Speculation
Sleep biology · Discovery ·
**Source:** europepmc · Origin: **US** · Lozano DE, Hong J, Jin X, Stucynski JA, Machens CK, Chung S, Weber F. · Nature neuroscience · 2026-05-25 **URL:** https://pubmed.n…
Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Wang Y, Kuang B, Chen Y, Zou W, Zheng L, Zhang B, Shang T, Xu C, Xu Q, Li H, Hu Y, Zhao K, Kuang H. · Journal of neuroinflammation ·…
SIRT5-dependent desuccinylation licenses UBR5-mediated degradation of TAMM41 to regulate mitochondrial metabolism in lung adenocarcinoma
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Yuan H, Hu W, Lv X, Cao Y, Hu K, Li Y, Chen Z, Yang J, Wang Y, Zhao J, Xu C. · Biology direct · 2026-05-25 **URL:** https://pubmed…
Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Wu Y, Fu T, Teng Y, Pan Y, Li L, Feng Y, Lin J. · Autophagy · 2026-05-25 **URL:** https://pubmed.ncbi.nlm.nih.gov/42186185/ **AI …
Diphlorethohydroxycarmalol isolated from &lt;i&gt;Ishige okamurae&lt;/i&gt; improves age-related muscle dysfunction by Ca&lt;sup&gt;2+&lt;/sup&gt;-dependent response &lt;i&gt;via&lt;/i&gt; the SirT1/PGC-1α pathway &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;i
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **KR** · Wang X, Kim CY, Je JG, Roh YJ, Yang F, Yang HW, Jeon YJ. · Food & function · 2026-05-26 **URL:** https://pubmed.ncbi.nlm.nih.gov/4…
Paeoniflorin Ameliorates Alcohol-Induced Depression via Modulating the Gut-Brain Axis and Inhibiting the NF-κB/NLRP3 Inflammasome Pathway in Mice
Speculation
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **CN** · Yu J, Zhang R, Quan Y, Sun D, Huang C, Xu J, Li X, Liu L. · Phytotherapy research : PTR · 2026-05-26 **URL:** https://pubmed.ncbi.…
Yajieshaba extract improves alcohol‑induced liver injury by regulating hepatic lipid metabolism and gut microbiota
Speculation
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Liping Y, Xingzhi Y, Jie T, Xiaohua D. · BMC complementary medicine and therapies · 2026-05-25 **URL:** https://pubmed.ncbi.nlm.ni…
Intermittent Theta-Burst Stimulation (iTBS) Improves Motor Coordination and Modulates Neuroinflammation and Autophagy in SCA3/MJD Mice
Speculation
Autophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **CN** · Chen LW, Lian YH, Dong XL, Luo KL, Zhan LQ, Xie LL, Sun QK, Lin W, Gan SR, Cheng XP, Ni J, Chen XY. · Cerebellum (London, England) ·…
MITF is essential for autophagy in the retinal pigment epithelium
Speculation
Autophagy & cellular renewal · Discovery ·
**Source:** europepmc · Garcia-Llorca A, Hermannsson K, Locri F, Andre H, Ogmundsdottir MH, Steingrimsson E, Eysteinsson T. · bioRxiv · 2026-05-25 **URL:** https://europepmc…
Regulatory impact of intermittent fasting on autophagy in high fat diet induced structural and cognitive brain deteriorations in rats
Speculation
Autophagy & cellular renewal · Discovery ·
**Source:** openalex · Mohamed Aref, Shimaa Hadhod, Nievin Ahmed Mahran, Haifa A. Alqahtani, Mohamed H. A. Gadelmawla · Scientific Reports · 2026-05-25 **URL:** https://doi.…
Impact of Chronic Mild Stress on Neurotrophic and Hypothalamic-Pituitary-Adrenal Factors in the Brain of Rats Submitted to Sepsis
Speculation
Stress biology · Discovery ·
**Source:** europepmc · Origin: **BR** · Peper-Nascimento J, Possamai-Della T, Gois-Carvalho T, Aguiar-Geraldo JM, Pescador B, Quevedo J, Dal-Pizzol F, Valvassor · Neurotoxic…
Enhancing Slow Wave Sleep in Depression
Speculation
Sleep biology · Discovery ·
**Source:** ctgov · Wake Forest University Health Sciences · NOT_YET_RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT07143838 **AI rationale (4/5, tier…
Sleep, Light, Circadian, Central Oxidative Stress
Speculation
Sleep biology · Discovery ·
**Source:** ctgov · Brigham and Women's Hospital · NOT_YET_RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT07471126 **AI rationale (4/5, tier: prelimin…
Cardiomyocyte BMAL1 deficiency worsens obesity-related cardiomyopathy with heightened PINK1/Parkin-linked mitophagy and mitochondrial dysfunction
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu T, Fan X, Zhang N, Wang Y, Qian Z, Hou X, Zhang H, Zou J. · Journal of biomedical research · 2026-05-25 **URL:** https://pubme…
Heterogeneous Mitochondrial Gene Expression in SH-SY5Y Cells Following ERRa and ERRy Depletion Reveals Divergent Stress Responses
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Mandel AR. · Research Square · 2026-05-25 **URL:** https://europepmc.org/article/PPR/PPR1237947 **AI rationale (4/5, tier: preliminary):** Mechanism…
Hirudin Promotes Peripheral Nerve Repair by Enhancing Mitophagy to Suppress NLRP3 Inflammasome Activation
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Yan R, Zhe Z, Zhang J, Lin T, Xiao S, Liu H, Mao H, Cooper T, Alqadhi S, Li B, Wu L. · Research Square · 2026-05-25 **URL:** https://europepmc.org/ar…
Inhibition of Mitochondrial Respiration Fragments ER Architecture and Remodels Organelle Contact Sites, as Revealed by FIB-SEM
Speculation
Mitochondrial biology · Discovery ·
**Source:** europepmc · Dlaskova A, Bazila B, Krepelka P, Victor RC, Jhala DJ, Jezek P. · bioRxiv · 2026-05-25 **URL:** https://europepmc.org/article/PPR/PPR1238456 **AI ra…
Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
Speculation
Mitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Yue Wang, Binglin Kuang, Chen Yangwen, Wei Zou, Lei Zheng · Journal of Neuroinflammation · 2026-05-25 **URL:** https://doi.org/10.1…
Gut Microbiota Dysbiosis Remodels the Multi-Tissue Transcriptional Landscape of the Host
Speculation
Microbiome ecology · Discovery ·
**Source:** europepmc · Huang L, Liu S, Xiao S, Li Y, Luo S, Hou E, Wang Y, Zong X. · Research Square · 2026-05-25 **URL:** https://europepmc.org/article/PPR/PPR1238149 **A…
Microbial and Environmental Factors Associated With Polyps Development in Familial Adenomatous Polyposis (MicrobEnvironment in FAP)
Microbiome ecology · Discovery ·
**Source:** ctgov · Hospices Civils de Lyon · RECRUITING · 2026-05-27 **URL:** https://clinicaltrials.gov/study/NCT06614738 **AI rationale (4/5, tier: unclassified):** Long…
Ulcerative colitis-driven gut dysbiosis exacerbates periodontal bone loss through the gut-oral axis /Th17/Treg imbalance
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Huang Y, Hu Y, Zhao Y, Li Y, Liu Y, Wang M, Wang Q, Hu H. · NPJ biofilms and microbiomes · 2026-05-23 **URL:** https://pubmed.ncbi…
Gut microbiome-mediated bioactive ingredients and health benefits of medicinal and edible fermented products: A comprehensive review
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu C, Zhang S, Yue Q, Sun X, Zheng K, Li K, Su L, Zhao L. · Folia microbiologica · 2026-05-23 **URL:** https://pubmed.ncbi.nlm.ni…
Multi-omics Analysis Reveals the Protection of a Quadruple Probiotic Mixture in Experimental Autoimmune Hepatitis
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Chen Y, Wang S, Chen A, Lin Z, Wang H, Li W, Liu J, Yao J, Tian D, Lei Y, Liu M. · Probiotics and antimicrobial proteins · 2026-05-…
Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Intestinal, Neurologic, and Cardiovascular Health: a Narrative Review
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CL** · Nieto ÁVA, Diaz AH, Millán MH, Sagredo D, Gacitua JA. · The Journal of nutritional biochemistry · 2026-05-23 **URL:** https://pubm…
Green tea polyphenol-iron oxide chitosan nanoparticles modulate gut microbiota and regulate metabolic pathways
Mucosa · Discovery ·
**Source:** europepmc · Origin: **MY** · Al Awawdeh S, Shafie NH, Ishak AH, Mohd Esa N, Loh SP, Nurdin A. · World journal of microbiology & biotechnology · 2026-05-25 **UR…
Intermittent fasting alleviates ulcerative colitis via lithocholic acid-mediated macrophage reprogramming
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Yujen Tseng, Lingxi Lin, Feng Ji, Huan Song, Le Chen · Frontiers in Nutrition · 2026-05-25 **URL:** https://doi.org/10.3389/fnut.20…
The Role of Vitamin D in Inflammatory Bowel Disease: Clinical Relevance and Therapeutic Potential
Mucosa · Discovery ·
**Source:** openalex · Origin: **PL** · Anna Drużdżel, Natalia Pawelec, Weronika Mazur, Marta Krzyżanowska, Kacper Curzytek · Quality in Sport · 2026-05-25 **URL:** https:…
Dietary Intervention with Brown Top Millet Starch Ameliorates Dyslipidaemia and Gut Leakiness in High Fat Diet Fed Models
Mucosa · Discovery ·
**Source:** openalex · Origin: **IN** · Ashish R. Chaudhari, Nandkishor R. Kotagale, Sandip Rahangdale · International Journal of Drug Delivery Technology · 2026-05-25 **U…
Combined heat and exercise stress disrupt gut microbiota and promote microbial translocation
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Leizi Min, Alimjan Ablitip, Q Q Wang, Ting Li, Qian Di · Frontiers in Microbiology · 2026-05-25 **URL:** https://doi.org/10.3389/fm…
Editorial: The role of gut microbiota in immune-related inflammatory diseases
Mucosa · Discovery ·
**Source:** openalex · Origin: **IT** · Cinzia Parolini, Núria Mach · Frontiers in Cellular and Infection Microbiology · 2026-05-25 **URL:** https://doi.org/10.3389/fcimb.…
Immunomodulatory Effects of Bifidobacterium bifidum BGN4 in Cyclophosphamide-induced Immunosuppressed Mice via Activation of NK Cells and Macrophages
Mucosa · Discovery ·
**Source:** openalex · Origin: **KR** · Seungil Kim, Ju Hye Song, Sang-Hyuk Yoo, Ji Yeon Yoo, Ji-Eun Eom · Probiotics and Antimicrobial Proteins · 2026-05-25 **URL:** http…
Sichuan dark tea with a medicine-food-homology formula synergistically alleviates alcohol-associated gut microbiota disturbance, liver steatosis and death in mice
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Fan Guo, Rong-Shuang Huang, Rui-Han Li, Yuying Feng, Lin Lin · DOAJ (DOAJ: Directory of Open Access Journals) · 2026-09-01 **URL:**…
Probiotic Intervention on the Development of Allergic Diseases in Infants Exposed to Antibiotics Early in Life
Mucosa · Discovery ·
**Source:** ctgov · Peking University Third Hospital · NOT_YET_RECRUITING · 2026-05-11 **URL:** https://clinicaltrials.gov/study/NCT07532421 **AI rationale (4/5, tier: uncl…
Mechanism of FODMAP Restriction on FGID Patients
Mucosa · Discovery ·
**Source:** ctgov · Universiti Kebangsaan Malaysia Medical Centre · RECRUITING · 2026-05-11 **URL:** https://clinicaltrials.gov/study/NCT07000227 **AI rationale (4/5, tier:…
Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function
Mucosa · Discovery ·
**Source:** ctgov · Mayo Clinic · COMPLETED · 2026-05-11 **URL:** https://clinicaltrials.gov/study/NCT05538247 **AI rationale (4/5, tier: unclassified):** Directly addresse…
Role of Akkermansia Muciniphila in Acne Vulgaris
Mucosa · Discovery ·
**Source:** ctgov · Medical University of South Carolina · NOT_YET_RECRUITING · 2026-05-12 **URL:** https://clinicaltrials.gov/study/NCT06992154 **AI rationale (4/5, tier: …
AKK Study in Improving Obesity and Metabolic Status in Children and Adolescents
Mucosa · Discovery ·
**Source:** ctgov · Central South University · NOT_YET_RECRUITING · 2026-05-18 **URL:** https://clinicaltrials.gov/study/NCT07593170 **AI rationale (4/5, tier: unclassified…
Gut Leakage' in Dengue
Mucosa · Discovery ·
**Source:** ctgov · University of Oxford · NOT_YET_RECRUITING · 2026-05-22 **URL:** https://clinicaltrials.gov/study/NCT07602920 **AI rationale (4/5, tier: unclassified):**…
Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV
Hypothesis
Chronic inflammation · Discovery ·
**Source:** ctgov · University of Hawaii · RECRUITING · 2026-05-27 **URL:** https://clinicaltrials.gov/study/NCT06935838 **AI rationale (4/5, tier: emerging):** Prospective…
The Role of Mitochondria in Polycystic Kidney Disease
Hypothesis
Mitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Yuhe Wang, Jianhua Mao, F Liu · International Journal of Molecular Sciences · 2026-05-26 **URL:** https://doi.org/10.3390/ijms27114…
Microbiota remodeling after bariatric surgery: Procedure-specific dynamics and metabolic implications
Hypothesis
Microbiome ecology · Discovery ·
**Source:** openalex · Zhi-Jie Qu, Shan Cong, Yang Cong, Yan Jiao, Ya-Hui Liu · World Journal of Gastrointestinal Surgery · 2026-05-27 **URL:** https://doi.org/10.4240/wjgs.…
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer
Hypothesis
Microbiome ecology · Discovery ·
**Source:** ctgov · University of Illinois at Chicago · COMPLETED · 2026-05-27 **URL:** https://clinicaltrials.gov/study/NCT04753359 **AI rationale (4/5, tier: emerging):**…
Gut Microbiome in AP Naive
Hypothesis
Microbiome ecology · Discovery ·
**Source:** ctgov · Centre for Addiction and Mental Health · ACTIVE_NOT_RECRUITING · 2026-05-27 **URL:** https://clinicaltrials.gov/study/NCT03414151 **AI rationale (4/5, t…
Influence of Probiotics on Early Gut Microbial Colonization
Hypothesis
Microbiome ecology · Discovery ·
**Source:** ctgov · BioGaia AB · NOT_YET_RECRUITING · 2026-05-27 **URL:** https://clinicaltrials.gov/study/NCT07608341 **AI rationale (4/5, tier: emerging):** RCT of probio…
The Effect of OptiFibre Dietary Fiber on Carbohydrate Metabolism and Intestinal Microbiota Metabolism in Patients With Type 2 Diabetes Mellitus
Hypothesis
Microbiome ecology · Discovery ·
**Source:** ctgov · Pirogov Russian National Research Medical University · COMPLETED · 2026-05-27 **URL:** https://clinicaltrials.gov/study/NCT07609992 **AI rationale (4/5,…
Comprehensive analysis of efferocytosis-related genes in diagnosis and immune infiltration in atherosclerosis: based on bulk and single-cell RNA sequencing data
Hypothesis
Resolution biology · Discovery ·
**Source:** openalex · Origin: **CN** · Jintao Qian, Junhao Zhang, Yì Wáng, Suyu Xu, Li Y · Frontiers in Cell and Developmental Biology · 2026-05-26 **URL:** https://doi.o…
Pharmacomicrobiomics of Non-Antibiotic Drugs: Mechanisms and Clinical Consequences of Gut Microbiota Alterations
Hypothesis
Mucosa · Discovery ·
**Source:** openalex · Origin: **RO** · Caterina Dumitru, Alina Oana Dumitru, Larisa Goroftei, Elena Niculeț, Mariana Daniela Ignat · Pharmaceutics · 2026-05-26 **URL:** h…
Beyond intestinal failure: Expanding therapeutic frontiers of glucagon-like peptide-2 in gastrointestinal disease
Hypothesis
Mucosa · Discovery ·
**Source:** openalex · Philippe Attieh, Dana Dabboussi, Wael Meraabi, Karam Karam, Rose Raymond Al Bacha · World Journal of Gastrointestinal Pharmacology and Therapeutics · 2…
Irisin-integrin αV/β5 coupling of α-synuclein phagocytosis and clearance
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu Y, Shi S, Zhang J, Huang M, Wang M, Zhang T, Wang W, Xiang J. · Journal of neuroinflammation · 2026-05-26 **URL:** https://pub…
FOXO transcription factors in Alzheimer's Disease: balancing neuroprotection and neuronal degeneration
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **IN** · Shyam M, Veronica A, Wadhwa J, Sharma V, B M O, Srirangan P, Venkatesh R, Evan Prince S. · Molecular biology reports · 2026-05-26 …
Distinct psychophysiological biomarkers and risk stratification models for irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D)
Hypothesis
Stress biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Chen X, Wang Y, Hou Y, Zhang L, Wu K, Wang C. · Scientific reports · 2026-05-25 **URL:** https://pubmed.ncbi.nlm.nih.gov/42185404/…
Repeated whole-body cryostimulation promotes a blood pressure reduction at rest in healthy adult men
Hypothesis
Stress biology · Discovery ·
**Source:** europepmc · Origin: **FR** · Jdidi H, de Bisschop C, Dugué B, Douzi W. · European journal of applied physiology · 2026-05-26 **URL:** https://pubmed.ncbi.nlm.n…
Mito_Plot: open-source pipeline for quantification and visualization of mitochondrial DNA heteroplasmy
Hypothesis
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **JP** · Nakamura K, Matsumoto N, Okazaki Y. · BMC bioinformatics · 2026-05-25 **URL:** https://pubmed.ncbi.nlm.nih.gov/42185947/ **AI rat…
Antimicrobial resistance and the human gut microbiome-a food safety perspective
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **IT** · Diaz-Amigo C, Bartolomé Del Pino LE, Lejeune J, Pinto Ferreira J, Bessy C. · Critical reviews in food science and nutrition · 2026-…
Integrated gut microbiota and metabolome signatures revealed by deep metagenomic sequencing in post-stroke cognitive impairment with type 2 diabetes
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu X, Kwok L-Y, Zhang W. · Microbiology spectrum · 2026-05-26 **URL:** https://pubmed.ncbi.nlm.nih.gov/42187250/ **AI rationale …
Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes by Targeting PF4<sup>+</sup> Macrophages in Acute Pancreatitis
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu L, Li G, Lu D, Ding H, Lu T, Sui Y, Zhang C, Xie Y, Kong R, Chen H, Bai X, Tan H, Xue D, Meng X, Li L, Sun B. · Advanced science …
Enterotype-specific microbial biomarkers of immune checkpoint inhibitor response revealed by large-scale integrated metagenomic analysis
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **IT** · Candeliere F, Busi E, Cerri S, Sola L, Lombardi M, Greco S, Pedroni S, Amaretti A, Raimondi S, Chiavelli C, Vitale MG, B · Cancer imm…
Effects of processed low-protein brown rice on patients with chronic kidney disease
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **JP** · Adachi K, Yasuda M, Ida M, Oshima Y, Azegami T, Yoshifuji A, Osada R, Oki I, Irie J, Kanda T, Takemura R, Hayashi K, Wak · Clinical a…
2-TIP QANDLI DIABET PATOGENEZIDA AUTOFAGIYA JARAYONINING ROLI VA INTERVAL OCHLIKNING BIOKIMYOVIY KORREKSIYASI
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** openalex · Ravshanoy Tursunova, Surayyo Boltayeva · Zenodo (CERN European Organization for Nuclear Research) · 2026-05-25 **URL:** https://doi.org/10.5281/zenodo…
Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** ctgov · Rapamycin Holdings Inc. · RECRUITING · 2026-05-22 **URL:** https://clinicaltrials.gov/study/NCT06950385 **AI rationale (4/5, tier: emerging):** Phase 3 …
Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** ctgov · Northwestern University · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT05576896 **AI rationale (4/5, tier: emerging):** Phase II…
Impact of Periodontal Inflammation on Allostatic Load
Hypothesis
Stress biology · Discovery ·
**Source:** ctgov · Postgraduate Institute of Dental Sciences Rohtak · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT06978712 **AI rationale (4/5, ti…
The Effect of Physiotherapy Integrated With Yoga and Mindfulness on Individuals With Fibromyalgia
Hypothesis
Stress biology · Discovery ·
**Source:** ctgov · University Hospital Tuebingen · ACTIVE_NOT_RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT07145788 **AI rationale (4/5, tier: emer…
Obstructive Sleep Apnoea and Difficult Asthma (OSADA)
Hypothesis
Sleep biology · Discovery ·
**Source:** ctgov · St. James's Hospital, Ireland · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT07160868 **AI rationale (4/5, tier: emerging):** RC…
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
Hypothesis
Sleep biology · Discovery ·
**Source:** ctgov · VA Office of Research and Development · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT02703207 **AI rationale (4/5, tier: emergin…
Population Based Lighting Study on Older Adults
Hypothesis
Sleep biology · Discovery ·
**Source:** ctgov · Azienda Usl di Bologna · COMPLETED · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT05676086 **AI rationale (4/5, tier: emerging):** Light-dark…
Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial
Hypothesis
Mitochondrial biology · Discovery ·
**Source:** ctgov · National Cancer Institute (NCI) · RECRUITING · 2026-05-13 **URL:** https://clinicaltrials.gov/study/NCT06022822 **AI rationale (4/5, tier: emerging):** …
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
Hypothesis
Mitochondrial biology · Discovery ·
**Source:** ctgov · Mario Negri Institute for Pharmacological Research · NOT_YET_RECRUITING · 2026-05-19 **URL:** https://clinicaltrials.gov/study/NCT07596615 **AI rational…
The human microbiome at translational crossroads: an ecological and causal perspective
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **SG** · Wong SH. · Singapore medical journal · 2026-05-25 **URL:** https://pubmed.ncbi.nlm.nih.gov/42184295/ **AI rationale (4/5, tier: e…
Letter to the Editor: Gut microbiota–bile acid crosstalk - Prevotellaceae NK3B31 and 7-ketolithocholic acid drive metabolic benefits of distal bowel resection with preservation of terminal ileum
Hypothesis
Microbiome ecology · Discovery ·
**Source:** openalex · Xu Cui, Long-Yao Xu, Bing-Qian Yin, liu chen, Zheng Liang · World Journal of Hepatology · 2026-05-26 **URL:** https://doi.org/10.4254/wjh.v18.i5.11551…
Westlake Frequent-sampling Cohort 2
Hypothesis
Microbiome ecology · Discovery ·
**Source:** ctgov · Westlake University · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT07606885 **AI rationale (4/5, tier: emerging):** Longitudinal…
Psyllium in Pediatric IBS
Hypothesis
Microbiome ecology · Discovery ·
**Source:** ctgov · Dr Bruno Chumpitazi, M.D. · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT06639984 **AI rationale (4/5, tier: emerging):** RCT me…
A single-strain dropout screen reveals mechanistic links between microbial ecology and metabolism
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Zeng X, Meng X, Weakley AM, Higginbottom SK, Lopez EM, Cabrera AV, Gray I, DeFelice B, Terasaki M, Zhao A, Hall KR, Levi · bioRxiv · 2026-05-25 **URL…
Gut microbiota-modulating interventions in paediatric type 1 diabetes: a systematic review and meta-analysis
Evidence
Microbiome ecology · Discovery ·
**Source:** europepmc · Origin: **ES** · Llopis-Alonso I, Correa-Bares M, Mercader-Ros MT, Lucas-Abellán C, García-Muñoz AM, Victoria-Montesinos D. · European journal of pedi…
Schistosoma mansoni infection is associated with changes in gut microbiota in preschool age children in Albertine Region, Uganda
Hypothesis
Microbiome ecology · Discovery ·
**Source:** europepmc · Edielu A, Lo C, Mawa PA, Webb EL, Elliott AM, Mugerwa JK, Oduru G, Nassuuna J, Ayebazibwe GK, Struebig M, Friedman JF, B · Research Square · 2026-05-2…
Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer's Disease: Mechanisms and Therapeutic Restoration
Hypothesis
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **EG** · Abdelaziz AM, Shokr MM, Fathy MK, Fawzy MN. · Journal of molecular neuroscience : MN · 2026-05-25 **URL:** https://pubmed.ncbi.nlm…
Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
Hypothesis
Mitochondrial biology · Discovery ·
**Source:** openalex · Kenneth P. Hough, Jennifer Trevor, Shaheer Ahmad, Yong Wang, Balu K. Chacko · Nature Communications · 2026-05-26 **URL:** https://doi.org/10.1038/s414…
NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells
Hypothesis
Mitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Cui J, Ren S, Wang B, Zhang N, Zhu S, Zhang Y, Qi X, Meng W, Shao L, Gao S, Xing L, Li Z, Mu X. · Autophagy · 2026-05-24 **URL:** …
1,25-Dihydroxyvitamin D3 mitigates high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in glomerular mesangial cells via the ROS/TXNIP/NLRP3 pathway
Speculation
Chronic inflammation · Discovery ·
**Source:** openalex · Origin: **CN** · Qingyue Meng, Bo Chen, Chunjiang Zhang, Lin Jia, Xingyu Yao · PubMed · 2026-06-01 **URL:** https://doi.org/10.14670/hh-25-021 **AI…
dlmoR: An open-source R package for the dim-light melatonin onset (DLMO) hockey-stick method
Hypothesis
Sleep biology · Discovery ·
**Source:** openalex · S. ; https://orcid.org/0009-0002-7320-9289 Thalji, M. ; https://orcid.org/0000-0002-8572-9268 Spitschan · MPG.PuRe (Max Planck Society) · 2026-06-01 *…
Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep
Hypothesis
Sleep biology · Discovery ·
**Source:** ctgov · Hospices Civils de Lyon · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT07605858 **AI rationale (4/5, tier: emerging):** Sleep fr…
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Hypothesis
Sleep biology · Discovery ·
**Source:** ctgov · University of California, San Diego · RECRUITING · 2026-05-26 **URL:** https://clinicaltrials.gov/study/NCT06548191 **AI rationale (4/5, tier: emerging)…
The Impacts of Trauma Exposure on Emotion Regulation and 2 Vagally Mediated Heart Rate Variability
Hypothesis
Stress biology · Discovery ·
**Source:** openalex · Rebeka Catherine Tucker · CLOK (University of Central Lancashire) · 2027-01-01 **URL:** https://doi.org/10.17030/uclan.thesis.00059261 **AI rationale…
Distinct psychophysiological biomarkers and risk stratification models for irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D)
Hypothesis
Stress biology · Discovery ·
**Source:** openalex · Origin: **CN** · X Chen, Yuxing Wang, Yanhong Hou, Li Zhang, Kai Wu · Scientific Reports · 2026-05-25 **URL:** https://doi.org/10.1038/s41598-026-50…
TREATMENT WITH MANDIBULAR ADVANCEMENT DEVICES IN COMORBID INSOMNIA AND SLEEP APNEA
Hypothesis
Stress biology · Discovery ·
**Source:** openalex · Origin: **BR** · Lílian Chrystiane Giannasi, D Gozal, Luís Vicente Franco Vilela, Marco Antônio Cardoso Machado, Mônica Fernandes Gomes · InterAmerican…
CHCHD2 and CHCHD10 promoted autophagic clearance of protein aggregates via GABARAPs
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **SG** · Wei Z, Zhang M, Tang W, Singh BK, Zhiwei Z, Lei Z, Goh Kim Wee J, Tan Rui En F, Jingxiu H, Qiaoyang S, Bin X, Priyanka G · Autophagy …
Mammalian Lysophagy: mechanisms and pathophysiological implications
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **CN** · Ji F, Dai M, Wang Z, Dai E, Kang R, Klionsky DJ, Tang D, Huang Y, Sun Y, Tong L. · Autophagy · 2026-05-25 **URL:** https://pubmed.…
Metformin-phytochemical combination therapy in metabolic dysfunction-associated steatotic liver disease: mechanistic insights and therapeutic potential
Hypothesis
Autophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **IR** · Amri J, Karimpour A, Meshkani R. · Naunyn-Schmiedeberg's archives of pharmacology · 2026-05-25 **URL:** https://pubmed.ncbi.nlm.ni…
Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
Speculation
Mucosa · Discovery · animal
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42177552/) **Authors:** Zou F, Wu Z, Wang S, Xu M, Xia P **Venue:** J Transl Med · 2026 May 23 **AI relevance (5/5):** Dire…
Resolution as an active process
Hypothesis
Resolution biology · Framework · mechanism_review
**Summary** For decades inflammation was understood as a single process that simply "wore off" once the trigger was removed. Resolution was passive — what happened when nothing mo…
Specialized pro-resolving mediators (SPMs)
Hypothesis
Resolution biology · Mediators · mechanism_review
**Summary** SPMs are bioactive lipid metabolites derived from polyunsaturated fatty acids. They include four families: lipoxins (from arachidonic acid), E-series resolvins (from E…
The omega-3 index as biomarker
Evidence
Resolution biology · Markers · mechanism_review
**Summary** The omega-3 index measures EPA + DHA as a percentage of total fatty acids in red blood cell phospholipids. It is the standardized, clinically-validated proxy for tissu…
The mucin barrier — architecture
Hypothesis
Mucosa · Architecture · mechanism_review
**Summary** The intestinal mucus barrier is more complex than commonly described. In the colon, there are two mucin layers: an inner, dense, sterile layer firmly attached to the e…
MUC2 glycosylation — the structural key
Hypothesis
Mucosa · Architecture · mechanism_review
**Summary** MUC2 — the dominant secreted mucin in the colon — is not protein with sugar attached. It is, by weight, mostly sugar. Up to eighty percent of the molecule's mass is it…
FUT2 secretor status — the testable genetic variable
Hypothesis
Mucosa · Genetic factors · mechanism_review
**Summary** The FUT2 (Secretor) gene encodes an α-1,2-fucosyltransferase responsible for expressing ABO histo-blood group antigens on gastrointestinal mucosa and in bodily secreti…
Resolution biology — SPMs (resolvins, protectins, maresins)
Hypothesis
Mucosa · Adjacent systems · mechanism_review
**Summary** Conceptually one of the most important paradigm shifts in inflammation research in the past 15 years, led by Charles Serhan at Harvard. Resolution of inflammation is n…
The sepsis-permeability feedback loop
Hypothesis
Mucosa · Mechanisms of dysfunction · mechanism_review
"Leaky gut → sepsis" is not a one-way mechanism. It is a self-reinforcing cycle. Both leaky gut (barrier defect at intestinal surface) and gut dysbiosis are intrinsic to sepsis. W…
Ileocecal vulnerability
Hypothesis
Mucosa · Mechanisms of dysfunction · mechanism_review
Patients with SIBO have significantly lower ileocecal pressure thresholds, prolonged small bowel transit time, and higher gastrointestinal pH compared to those without SIBO. The s…
Butyrate and SCFAs — the central fuel
Hypothesis
Mucosa · Microbiome interface · mechanism_review
Goblet cells and colonocytes run on butyrate as primary energy source. This is not incidental. Butyrate serves as a key energy substrate for goblet cells producing MUC2 and protec…
Akkermansia muciniphila and the mucolytic balance
Hypothesis
Mucosa · Microbiome interface · mechanism_review
Akkermansia muciniphila colonizes the mucosal layer of the human gut. It is particularly effective at increasing mucus thickness and improving barrier function. A. muciniphila rest…
Bile acids as signaling molecules — FXR and TGR5
Hypothesis
Mucosa · Microbiome interface · mechanism_review
Bile acids are not just fat emulsifiers. They are signaling molecules. The intestinal epithelium prominently expresses two key bile acid receptors — farnesoid X receptor (FXR) and…
Paneth cells and α-defensins (HD5, HD6)
Hypothesis
Mucosa · Architecture · mechanism_review
The small intestine has its own specialized defense system: Paneth cells at the bottom of the crypts of Lieberkühn, which produce potent antimicrobial peptides — particularly HD5 a…
Mast cells and mucus hypersecretion (MCAS)
Hypothesis
Mucosa · Adjacent systems · human_observational
Mast cell activation syndrome (MCAS) is a differential consideration in any picture combining inflammation escalation, mucus hypersecretion, and food intolerance patterns. Mast ce…
The vagus nerve and the cholinergic anti-inflammatory pathway
Hypothesis
Mucosa · Adjacent systems · mixed
The vagus nerve has anti-inflammatory properties through its afferents (activating HPA) and its efferents (the cholinergic anti-inflammatory pathway, CAP). The CAP inhibits pro-inf…
The glycocalyx and heparan sulfate / syndecan-1
Hypothesis
Mucosa · Architecture · mechanism_review
A third barrier system, often overlooked in clinical discussion: the glycocalyx layer on the basolateral side of enterocytes, primarily based on heparan sulfate proteoglycans (espe…
Trefoil factors (TFF1, TFF2, TFF3) — the active repair system
Hypothesis
Mucosa · Architecture · mechanism_review
If SCFAs fuel the goblet cells, trefoil factors are the active repair signal. These small peptides are underappreciated and directly relevant. Trefoil peptides play important role…
Dietary emulsifiers and mucus barrier damage
Hypothesis
Mucosa · Interventions · mixed
Specific food additives have surprisingly strong evidence for mucus barrier damage. Consumption of generally-regarded-as-safe emulsifiers has increased, and is associated with inc…
FMT — fecal microbiota transplantation
Evidence
Mucosa · Interventions · mechanism_review
FMT has moved from experimental to standard treatment for specific indications. FMT resolution of recurrent C. difficile infection: 81–95% across academic and private settings. FM…
The integrated mechanistic model
Speculation
Mucosa · Synthesis · mechanism_review
When all of this is integrated, a pattern emerges that may match many escalating mucosal-disease pictures. **The primary lesion (hypothesis):** defective mucin glycosylation — eit…