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All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.
Topic
Evidence tier
55 articles of 156
LEF1 gene mutation impairs the intestinal barrier and causes diarrhea
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42176141/)
**Authors:** Jie J, Qiu M, Liu X, Zhang Q, Xie J
**Venue:** Mol Cell Pediatr · 2026 May 23
**AI relevance (5/5):…
Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin-Active Carbohydrate Sulfatases
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42175861/)
**Authors:** Tomlinson CWE, Bergers MD, Bolam DN, Luis AS, Cartmell A
**Venue:** Angew Chem Int Ed Engl · 2026 May…
Faecalibacterium prausnitzii-derived extracellular vesicles ameliorate experimental colitis through regulating barrier immunity and gut microbiota
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42173875/)
**Authors:** Nie X, Li Q, Tao Z, Xu Y, Li B
**Venue:** NPJ Sci Food · 2026 May 23
**AI relevance (5/5):** F. pra…
Phellinus linteus polysaccharides alleviate DSS-induced colitis in mice by restoring gut microbiota homeostasis, preserving intestinal barrier integrity, and attenuating JAK2/STAT3-associated inflammatory signaling
Mucosa · Discovery ·
**Source:** [biorxiv](https://doi.org/10.21203/rs.3.rs-9420434/v1)
**Authors:** Xu L, Yang Y, Shi C, Li G
**Venue:** bioRxiv (preprint) ·
**AI relevance (5/5):** Directly addr…
Effect of Oral Calcium Butyrate Supplementation in Obesity
Mucosa · Discovery ·
**Source:** [ctgov](https://clinicaltrials.gov/study/NCT07583017)
**Authors:** Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
**Venue:** NOT_YET_RECRUITING ·…
Polysaccharide from Atractylodes macrocephala Koidz. protects against avian pathogenic Escherichia coli-induced intestinal barrier Dysfunction via Suppressing PI3K/Akt-Mediated Claudin-2 upregulation
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42184735/)
**Authors:** Chen S, Qu X, Wu J
**Venue:** Poult Sci · 2026 May 15
**AI relevance (5/5):** Directly addresses in…
Dietary dimethylglycine alleviates cyclic heat stress-induced jejunal injury in yellow-feathered broilers by inhibiting the TLR4/NF-κB signaling pathway and restoring MUC2 expression
Mucosa · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42184641/)
**Authors:** Shao D, Hu L, Guo W, Chen J, Guo X
**Venue:** Poult Sci · 2026 May 21
**AI relevance (5/5):** Direc…
Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42177552/)
**Authors:** Zou F, Wu Z, Wang S, Xu M, Xia P, Hu Y, Fang T, Hu P, Huang C, Deng F.
**Venue:** Journal of trans…
Personalized barrier recovery induced by Lactobacillus helveticus SBT2171 in an In Vitro model of ulcerative colitis-derived fecal supernatants
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42177520/)
**Authors:** Khademi M, Kazemifard N, Fathi M, Farmani M, Baradaran Ghavami S, Khanabadi B, Shahrokh S.
**Venue…
Rapid early life colonization of the intestinal tract by Akkermansia muciniphila after voluntary feeding
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42177437/)
**Authors:** Dumlao JM, McCallum P, Hodak CR, Guinto E, Enns W, Davey LE, Choy JC.
**Venue:** BMC microbiology …
LEF1 gene mutation impairs the intestinal barrier and causes diarrhea
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42176141/)
**Authors:** Jie J, Qiu M, Liu X, Zhang Q, Xie J, Geng L, Gong S, Cheng Y.
**Venue:** Molecular and cellular pe…
Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin-Active Carbohydrate Sulfatases
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42175861/)
**Authors:** Tomlinson CWE, Bergers MD, Bolam DN, Luis AS, Cartmell A, Armstrong Z.
**Venue:** Angewandte Chemi…
Faecalibacterium prausnitzii-derived extracellular vesicles ameliorate experimental colitis through regulating barrier immunity and gut microbiota
Mucosa · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42173875/)
**Authors:** Nie X, Li Q, Tao Z, Xu Y, Li B, Xie J, Nie S.
**Venue:** NPJ science of food · 2026-05-23
**Abst…
Anti-inflammatory and gut microbiota-modulating effects of a novel mannan from Scilla scilloides on DSS-induced colitis in mice
SpeculationMucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Yuanhao Qiu, Zihan Liu, Weishuang Tong, Weiwei Fan, Aoying Zhang · Journal of Functional Foods · 2026-05-26
**URL:** https://doi.or…
Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages
SpeculationMucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Shenghao Xv, Jie Hao, Sanhua Deng, Zhengyin Zhang, Runshu Wang · Frontiers in Immunology · 2026-05-26
**URL:** https://doi.org/10.3…
Eubacterium rectale Mitigates Inflammatory Bowel Disease via Modulation of Glutamine Metabolism Through the GLS2 and NF-κB Pathway
SpeculationMucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Lu Han, Yiyi Jin, Wen Lin, Zide Liu, Chunyan Zeng · npj Science of Food · 2026-05-26
**URL:** https://doi.org/10.1038/s41538-026-00…
Yajieshaba extract improves alcohol‑induced liver injury by regulating hepatic lipid metabolism and gut microbiota
SpeculationMucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Liping Y, Xingzhi Y, Jie T, Xiaohua D. · BMC complementary medicine and therapies · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.ni…
Ulcerative colitis-driven gut dysbiosis exacerbates periodontal bone loss through the gut-oral axis /Th17/Treg imbalance
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Huang Y, Hu Y, Zhao Y, Li Y, Liu Y, Wang M, Wang Q, Hu H. · NPJ biofilms and microbiomes · 2026-05-23
**URL:** https://pubmed.ncbi…
Gut microbiome-mediated bioactive ingredients and health benefits of medicinal and edible fermented products: A comprehensive review
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu C, Zhang S, Yue Q, Sun X, Zheng K, Li K, Su L, Zhao L. · Folia microbiologica · 2026-05-23
**URL:** https://pubmed.ncbi.nlm.ni…
Multi-omics Analysis Reveals the Protection of a Quadruple Probiotic Mixture in Experimental Autoimmune Hepatitis
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Chen Y, Wang S, Chen A, Lin Z, Wang H, Li W, Liu J, Yao J, Tian D, Lei Y, Liu M. · Probiotics and antimicrobial proteins · 2026-05-…
Molecular Pathways and Clinical Applications of Probiotics as Effective Supporters of Intestinal, Neurologic, and Cardiovascular Health: a Narrative Review
Mucosa · Discovery ·
**Source:** europepmc · Origin: **CL** · Nieto ÁVA, Diaz AH, Millán MH, Sagredo D, Gacitua JA. · The Journal of nutritional biochemistry · 2026-05-23
**URL:** https://pubm…
Green tea polyphenol-iron oxide chitosan nanoparticles modulate gut microbiota and regulate metabolic pathways
Mucosa · Discovery ·
**Source:** europepmc · Origin: **MY** · Al Awawdeh S, Shafie NH, Ishak AH, Mohd Esa N, Loh SP, Nurdin A. · World journal of microbiology & biotechnology · 2026-05-25
**UR…
Intermittent fasting alleviates ulcerative colitis via lithocholic acid-mediated macrophage reprogramming
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Yujen Tseng, Lingxi Lin, Feng Ji, Huan Song, Le Chen · Frontiers in Nutrition · 2026-05-25
**URL:** https://doi.org/10.3389/fnut.20…
The Role of Vitamin D in Inflammatory Bowel Disease: Clinical Relevance and Therapeutic Potential
Mucosa · Discovery ·
**Source:** openalex · Origin: **PL** · Anna Drużdżel, Natalia Pawelec, Weronika Mazur, Marta Krzyżanowska, Kacper Curzytek · Quality in Sport · 2026-05-25
**URL:** https:…
Dietary Intervention with Brown Top Millet Starch Ameliorates Dyslipidaemia and Gut Leakiness in High Fat Diet Fed Models
Mucosa · Discovery ·
**Source:** openalex · Origin: **IN** · Ashish R. Chaudhari, Nandkishor R. Kotagale, Sandip Rahangdale · International Journal of Drug Delivery Technology · 2026-05-25
**U…
Combined heat and exercise stress disrupt gut microbiota and promote microbial translocation
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Leizi Min, Alimjan Ablitip, Q Q Wang, Ting Li, Qian Di · Frontiers in Microbiology · 2026-05-25
**URL:** https://doi.org/10.3389/fm…
Editorial: The role of gut microbiota in immune-related inflammatory diseases
Mucosa · Discovery ·
**Source:** openalex · Origin: **IT** · Cinzia Parolini, Núria Mach · Frontiers in Cellular and Infection Microbiology · 2026-05-25
**URL:** https://doi.org/10.3389/fcimb.…
Immunomodulatory Effects of Bifidobacterium bifidum BGN4 in Cyclophosphamide-induced Immunosuppressed Mice via Activation of NK Cells and Macrophages
Mucosa · Discovery ·
**Source:** openalex · Origin: **KR** · Seungil Kim, Ju Hye Song, Sang-Hyuk Yoo, Ji Yeon Yoo, Ji-Eun Eom · Probiotics and Antimicrobial Proteins · 2026-05-25
**URL:** http…
Sichuan dark tea with a medicine-food-homology formula synergistically alleviates alcohol-associated gut microbiota disturbance, liver steatosis and death in mice
Mucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Fan Guo, Rong-Shuang Huang, Rui-Han Li, Yuying Feng, Lin Lin · DOAJ (DOAJ: Directory of Open Access Journals) · 2026-09-01
**URL:**…
Probiotic Intervention on the Development of Allergic Diseases in Infants Exposed to Antibiotics Early in Life
Mucosa · Discovery ·
**Source:** ctgov · Peking University Third Hospital · NOT_YET_RECRUITING · 2026-05-11
**URL:** https://clinicaltrials.gov/study/NCT07532421
**AI rationale (4/5, tier: uncl…
Mechanism of FODMAP Restriction on FGID Patients
Mucosa · Discovery ·
**Source:** ctgov · Universiti Kebangsaan Malaysia Medical Centre · RECRUITING · 2026-05-11
**URL:** https://clinicaltrials.gov/study/NCT07000227
**AI rationale (4/5, tier:…
Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function
Mucosa · Discovery ·
**Source:** ctgov · Mayo Clinic · COMPLETED · 2026-05-11
**URL:** https://clinicaltrials.gov/study/NCT05538247
**AI rationale (4/5, tier: unclassified):** Directly addresse…
Role of Akkermansia Muciniphila in Acne Vulgaris
Mucosa · Discovery ·
**Source:** ctgov · Medical University of South Carolina · NOT_YET_RECRUITING · 2026-05-12
**URL:** https://clinicaltrials.gov/study/NCT06992154
**AI rationale (4/5, tier: …
AKK Study in Improving Obesity and Metabolic Status in Children and Adolescents
Mucosa · Discovery ·
**Source:** ctgov · Central South University · NOT_YET_RECRUITING · 2026-05-18
**URL:** https://clinicaltrials.gov/study/NCT07593170
**AI rationale (4/5, tier: unclassified…
Gut Leakage' in Dengue
Mucosa · Discovery ·
**Source:** ctgov · University of Oxford · NOT_YET_RECRUITING · 2026-05-22
**URL:** https://clinicaltrials.gov/study/NCT07602920
**AI rationale (4/5, tier: unclassified):**…
Pharmacomicrobiomics of Non-Antibiotic Drugs: Mechanisms and Clinical Consequences of Gut Microbiota Alterations
HypothesisMucosa · Discovery ·
**Source:** openalex · Origin: **RO** · Caterina Dumitru, Alina Oana Dumitru, Larisa Goroftei, Elena Niculeț, Mariana Daniela Ignat · Pharmaceutics · 2026-05-26
**URL:** h…
Beyond intestinal failure: Expanding therapeutic frontiers of glucagon-like peptide-2 in gastrointestinal disease
HypothesisMucosa · Discovery ·
**Source:** openalex · Philippe Attieh, Dana Dabboussi, Wael Meraabi, Karam Karam, Rose Raymond Al Bacha · World Journal of Gastrointestinal Pharmacology and Therapeutics · 2…
Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
SpeculationMucosa · Discovery · animal
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42177552/)
**Authors:** Zou F, Wu Z, Wang S, Xu M, Xia P
**Venue:** J Transl Med · 2026 May 23
**AI relevance (5/5):** Dire…
The mucin barrier — architecture
HypothesisMucosa · Architecture · mechanism_review
**Summary**
The intestinal mucus barrier is more complex than commonly described. In the colon, there are two mucin layers: an inner, dense, sterile layer firmly attached to the e…
MUC2 glycosylation — the structural key
HypothesisMucosa · Architecture · mechanism_review
**Summary**
MUC2 — the dominant secreted mucin in the colon — is not protein with sugar attached. It is, by weight, mostly sugar. Up to eighty percent of the molecule's mass is it…
FUT2 secretor status — the testable genetic variable
HypothesisMucosa · Genetic factors · mechanism_review
**Summary**
The FUT2 (Secretor) gene encodes an α-1,2-fucosyltransferase responsible for expressing ABO histo-blood group antigens on gastrointestinal mucosa and in bodily secreti…
Resolution biology — SPMs (resolvins, protectins, maresins)
HypothesisMucosa · Adjacent systems · mechanism_review
**Summary**
Conceptually one of the most important paradigm shifts in inflammation research in the past 15 years, led by Charles Serhan at Harvard. Resolution of inflammation is n…
The sepsis-permeability feedback loop
HypothesisMucosa · Mechanisms of dysfunction · mechanism_review
"Leaky gut → sepsis" is not a one-way mechanism. It is a self-reinforcing cycle.
Both leaky gut (barrier defect at intestinal surface) and gut dysbiosis are intrinsic to sepsis. W…
Ileocecal vulnerability
HypothesisMucosa · Mechanisms of dysfunction · mechanism_review
Patients with SIBO have significantly lower ileocecal pressure thresholds, prolonged small bowel transit time, and higher gastrointestinal pH compared to those without SIBO.
The s…
Butyrate and SCFAs — the central fuel
HypothesisMucosa · Microbiome interface · mechanism_review
Goblet cells and colonocytes run on butyrate as primary energy source. This is not incidental.
Butyrate serves as a key energy substrate for goblet cells producing MUC2 and protec…
Akkermansia muciniphila and the mucolytic balance
HypothesisMucosa · Microbiome interface · mechanism_review
Akkermansia muciniphila colonizes the mucosal layer of the human gut. It is particularly effective at increasing mucus thickness and improving barrier function. A. muciniphila rest…
Bile acids as signaling molecules — FXR and TGR5
HypothesisMucosa · Microbiome interface · mechanism_review
Bile acids are not just fat emulsifiers. They are signaling molecules.
The intestinal epithelium prominently expresses two key bile acid receptors — farnesoid X receptor (FXR) and…
Paneth cells and α-defensins (HD5, HD6)
HypothesisMucosa · Architecture · mechanism_review
The small intestine has its own specialized defense system: Paneth cells at the bottom of the crypts of Lieberkühn, which produce potent antimicrobial peptides — particularly HD5 a…
Mast cells and mucus hypersecretion (MCAS)
HypothesisMucosa · Adjacent systems · human_observational
Mast cell activation syndrome (MCAS) is a differential consideration in any picture combining inflammation escalation, mucus hypersecretion, and food intolerance patterns.
Mast ce…
The vagus nerve and the cholinergic anti-inflammatory pathway
HypothesisMucosa · Adjacent systems · mixed
The vagus nerve has anti-inflammatory properties through its afferents (activating HPA) and its efferents (the cholinergic anti-inflammatory pathway, CAP). The CAP inhibits pro-inf…
The glycocalyx and heparan sulfate / syndecan-1
HypothesisMucosa · Architecture · mechanism_review
A third barrier system, often overlooked in clinical discussion: the glycocalyx layer on the basolateral side of enterocytes, primarily based on heparan sulfate proteoglycans (espe…
Trefoil factors (TFF1, TFF2, TFF3) — the active repair system
HypothesisMucosa · Architecture · mechanism_review
If SCFAs fuel the goblet cells, trefoil factors are the active repair signal. These small peptides are underappreciated and directly relevant.
Trefoil peptides play important role…
Dietary emulsifiers and mucus barrier damage
HypothesisMucosa · Interventions · mixed
Specific food additives have surprisingly strong evidence for mucus barrier damage.
Consumption of generally-regarded-as-safe emulsifiers has increased, and is associated with inc…
FMT — fecal microbiota transplantation
EvidenceMucosa · Interventions · mechanism_review
FMT has moved from experimental to standard treatment for specific indications.
FMT resolution of recurrent C. difficile infection: 81–95% across academic and private settings. FM…
The integrated mechanistic model
SpeculationMucosa · Synthesis · mechanism_review
When all of this is integrated, a pattern emerges that may match many escalating mucosal-disease pictures.
**The primary lesion (hypothesis):** defective mucin glycosylation — eit…