Bionoia Where life meets thought ⌕
Back to Journal
Journal › Mucosa
Discovery

Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function

Read original paper
Editor's note
Intestinal barrier dysfunction underpins everything from inflammatory bowel disease to food sensitivities, yet proven interventions remain scarce. This completed trial directly tests whether a specific probiotic strain can restore barrier integrity—a mechanistic question that sits at the intersection of microbiome science and practical clinical need. Gastroenterologists, functional medicine practitioners, and researchers studying leaky gut should watch for results that could reshape how we approach permeability-driven inflammation.

Source: ctgov · Mayo Clinic · COMPLETED · 2026-05-11

URL: https://clinicaltrials.gov/study/NCT05538247

AI rationale (4/5, tier: unclassified): Directly addresses intestinal barrier function and permeability; probiotic mechanism relevant to mucosa-host signalling.

This study is being done to assess the effects of S. boulardii CNCM I-745 compared to placebo on impaired intestinal permeability, which is the control of material passing from inside the gastrointestinal tract through the cells lining the gut wall into the rest of the body.

Related articles in this corpus

Parallel
Bile acids as signaling molecules — FXR and TGR5
Both articles address intestinal barrier function maintenance through different mechanisms—Article A examines S. boulardii's effects on permeability while Article B describes bile acid signaling pathways (FXR/TGR5) that regulate the same barrier integrity.
Parallel
Eubacterium rectale Mitigates Inflammatory Bowel Disease via Modulation of Glutamine Metabolism Through the GLS2 and NF-κB Pathway
Both articles investigate how specific microorganisms restore intestinal barrier integrity in gastrointestinal dysfunction, but employ different organisms and disease models to address the same therapeutic outcome.
Parallel
Trefoil factors (TFF1, TFF2, TFF3) — the active repair system
Both articles address intestinal barrier function and permeability through different mechanisms—Article A examines S. boulardii's effects on barrier integrity while Article B explains trefoil factors' role in the same barrier maintenance and tight junction regulation.
Parallel
Ileocecal vulnerability
Both articles address intestinal barrier dysfunction in SIBO pathology—Article A identifies the structural and functional deficits enabling bacterial translocation, while Article B investigates a probiotic intervention targeting the impaired intestinal permeability that results from these deficits.
Parallel
The vagus nerve and the cholinergic anti-inflammatory pathway
Both articles address intestinal barrier function and permeability reduction through different mechanisms (vagus nerve stimulation via CAP in Article A, probiotic supplementation in Article B), but neither directly builds on or contradicts the other's findings.
Published 2026-05-28 · Last kit-update 2026-05-28