Mucosa
The body's most consequential interface
Mucosa is where tissue meets world. Many of medicine's hardest questions still lie open here — barrier dysfunction, microbiome-host signalling, resolution biology. This topic curates the current evidence with citation rigor.
Klaus Theede: Measuring What Matters in IBD
Klaus Theede is a gastroenterologist and clinical researcher at Amager og Hvidovre Hospital in Copenhagen, where he works within the Gastro-medicinsk Afdeling. Trained as both a clinician and a scientist — he holds an MD and a PhD — Theede occupies a practical position in the field: he is interested in what happens between a patient's last appointment and the next flare, and…
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77 articles in Mucosa, sorted by date
LEF1 gene mutation impairs the intestinal barrier and causes diarrhea
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Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin-Active Carbohydrate Sulfatases
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Faecalibacterium prausnitzii-derived extracellular vesicles ameliorate experimental colitis through regulating barrier immunity and gut microbiota
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Phellinus linteus polysaccharides alleviate DSS-induced colitis in mice by restoring gut microbiota homeostasis, preserving intestinal barrier integrity, and attenuating JAK2/STAT3-associated inflammatory signaling
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Effect of Oral Calcium Butyrate Supplementation in Obesity
Obesity is characterized by gut microbiota dysbiosis, in which beneficial metabolites such as butyrate are reduced. Butyrate is a short-chain fatty acid produced by microbial…
Read article →Polysaccharide from Atractylodes macrocephala Koidz. protects against avian pathogenic Escherichia coli-induced intestinal barrier Dysfunction via Suppressing PI3K/Akt-Mediated Claudin-2 upregulation
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Dietary dimethylglycine alleviates cyclic heat stress-induced jejunal injury in yellow-feathered broilers by inhibiting the TLR4/NF-κB signaling pathway and restoring MUC2 expression
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Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
<h4>Background</h4>Intestinal barrier defects cause antigen translocation and immune dysregulation. The pyroptosis of colonic epithelial cells (CECs) disrupts the colonic barrier,…
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Personalized barrier recovery induced by Lactobacillus helveticus SBT2171 in an In Vitro model of ulcerative colitis-derived fecal supernatants
<h4>Background</h4>Disruption of the intestinal epithelial barrier is a hallmark of inflammatory bowel disease (IBD). Although probiotics and postbiotics are increasingly…
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