Sleep biology
Why we sleep — circadian rhythms and the glymphatic system
Sleep is when the brain self-cleans, the immune system consolidates, and memory is encoded. This topic curates the evidence on why sleep matters — biologically, not just behaviourally.
Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming
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18 articles in Sleep biology, sorted by date
Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity
This study aims to stabilize the patients with bipolar disorder (BD) comorbid with obesity in the stable phase by using temporal interference stimulation (TIS ) intervention. It…
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Influence of Intermittent Hypoxia on Loop Gain in Healthy Subjects
Sleep apnoea-hypopnoea syndrome (SAHOS), which causes numerous comorbidities, particularly cardiovascular ones, is widespread worldwide today and incurs significant healthcare…
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METTL14 Regulates Adipose Tissue Macrophage Polarization via JAK2 / STAT3 Pathway to Attenuate Obstructive Sleep Apnea‐Related Systemic Inflammation
ABSTRACT The role of m 6 A RNA methylation in obstructive sleep apnea (OSA)‐related metabolic dysfunction and systemic inflammation is unknown. We aimed to identify the key m 6 A…
Read article →Effects of chronic jetlag on high-fat and high-fructose diet induced renal injury in mice
Chronic disruption of the circadian rhythm caused by factors such as jetlag has been associated with increased risks of obesity and chronic kidney disease. Although obesity is a…
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Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Naïve Alzheimer's disease
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The CLOCK-BMAL1 complex in circadian regulation: structure, mechanisms, and therapeutic targeting
The heterodimeric transcription factor CLOCK-BMAL1 functions as the central activator of the mammalian circadian clock. By integrating basic helix-loop-helix (bHLH) and PAS-domain…
Read article →Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Naïve Alzheimer's disease
<h4>Background</h4>Obstructive sleep apnea (OSA) is highly prevalent in Alzheimer's disease (AD) patients and is associated with cognitive decline. However, the mechanisms linking…
Read article →Sleep and Performance
This research is being done to apply new, contrast-free MRI (Magnetic Resonance Imaging) methods to understand the brain's waste clearance system (the "glymphatic" system) in…
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Low-dimensional population dynamics in the brainstem gate REM sleep
Rapid-eye-movement (REM) sleep is generated in the brainstem, but the brainstem population dynamics that drive transitions to REM sleep remain largely unknown. Here, combining…
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