Autophagy & cellular renewal
Cellular self-eating — the renewal pathway
Autophagy is how cells remove damaged components and recycle nutrients. When it fails, neurodegeneration follows. When it's well-tuned, lifespan extends. This topic curates the evidence on autophagy biology and its clinical implications.
PRRSV NSP2 hijacks host lipophagy via a LIPE-PNPLA2-AMPK-MTOR axis to promote viral replication
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16 articles in Autophagy & cellular renewal, sorted by date
Corrigendum to “Lithium ameliorates spinal cord injury through endoplasmic reticulum stress-regulated autophagy and alleviated apoptosis through IRE1 and PERK/eIF2α signaling pathways” [J Neurorestoratol 11 (2023) 100081]
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FOXO transcription factors in Alzheimer’s Disease: balancing neuroprotection and neuronal degeneration
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The Mechanistic Crosstalk between Probiotics, ncRNAs, and Autophagy: Implications for Colorectal Cancer Precision Medicine
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Mechanism of Inonotus hispidus in suppressing renal cell carcinoma proliferation via regulation of the PI3K/AKT/mTOR pathway
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Read article →Intermittent Theta-Burst Stimulation (iTBS) Improves Motor Coordination and Modulates Neuroinflammation and Autophagy in SCA3/MJD Mice
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disorder characterized by misfolded ataxin-3 aggregation and neuronal…
Read article →MITF is essential for autophagy in the retinal pigment epithelium
The Microphthalmia-associated transcription factor (MITF) plays a critical role in retinal pigment epithelium (RPE) development and function. Dysfunctional autophagy and lysosomal…
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Regulatory impact of intermittent fasting on autophagy in high fat diet induced structural and cognitive brain deteriorations in rats
Abstract Obesity-induced cognitive decline has been linked to alterations in brain autophagy. However, research concerning the high-fat diet (HFD) impacts on the brain still lacks…
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Irisin-integrin αV/β5 coupling of α-synuclein phagocytosis and clearance
Parkinson's disease-associated cognitive impairment (PD-CI) is closely linked to α-synuclein (α-syn) accumulation and synaptic dysfunction, yet effective disease-modifying…
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FOXO transcription factors in Alzheimer's Disease: balancing neuroprotection and neuronal degeneration
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by the accumulation of amyloid-β, hyperphosphorylation of tau, oxidative stress, synaptic dysfunction,…
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