Autophagy & cellular renewal
Cellular self-eating — the renewal pathway
Autophagy is how cells remove damaged components and recycle nutrients. When it fails, neurodegeneration follows. When it's well-tuned, lifespan extends. This topic curates the evidence on autophagy biology and its clinical implications.
Intermittent Theta-Burst Stimulation (iTBS) Improves Motor Coordination and Modulates Neuroinflammation and Autophagy in SCA3/MJD Mice
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disorder characterized by misfolded ataxin-3 aggregation and neuronal intranuclear inclusions. Its primary symptom is progressive ataxia, progressively restricting daily living activities. While repetitive transcranial magnetic stimulation (rTMS) may alleviate symptoms,…
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3 articles in Autophagy & cellular renewal tagged Speculation, sorted by date
MITF is essential for autophagy in the retinal pigment epithelium
The Microphthalmia-associated transcription factor (MITF) plays a critical role in retinal pigment epithelium (RPE) development and function. Dysfunctional autophagy and lysosomal…
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Regulatory impact of intermittent fasting on autophagy in high fat diet induced structural and cognitive brain deteriorations in rats
Abstract Obesity-induced cognitive decline has been linked to alterations in brain autophagy. However, research concerning the high-fat diet (HFD) impacts on the brain still lacks…
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