Autophagy & cellular renewal
Cellular self-eating — the renewal pathway
Autophagy is how cells remove damaged components and recycle nutrients. When it fails, neurodegeneration follows. When it's well-tuned, lifespan extends. This topic curates the evidence on autophagy biology and its clinical implications.
Irisin-integrin αV/β5 coupling of α-synuclein phagocytosis and clearance
Parkinson's disease-associated cognitive impairment (PD-CI) is closely linked to α-synuclein (α-syn) accumulation and synaptic dysfunction, yet effective disease-modifying strategies remain limited. Irisin is an exercise-inducible myokine with neuroprotective potential, but its receptor mechanisms and its role in α-syn clearance in PD-CI are poorly defined. Here, we observed…
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8 articles in Autophagy & cellular renewal tagged Hypothesis, sorted by date
FOXO transcription factors in Alzheimer's Disease: balancing neuroprotection and neuronal degeneration
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by the accumulation of amyloid-β, hyperphosphorylation of tau, oxidative stress, synaptic dysfunction,…
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2-TIP QANDLI DIABET PATOGENEZIDA AUTOFAGIYA JARAYONINING ROLI VA INTERVAL OCHLIKNING BIOKIMYOVIY KORREKSIYASI
Dunyo miqyosida 2-tip qandli diabet (T2DM) patogenezida hujayra darajasidagi metabolik disfunksiya asosiy omil bo‘lib qolmoqda. Ushbu maqolada surunkali giperinsulinemiya…
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Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
The main goal of this clinical trial is to learn if the drug eRapa works to slow down the progression of disease in patients diagnosed with Familial Adenomatous Polyposis (FAP).…
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Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
This is a Phase II, open label, single-arm trial study of adding hydroxychloroquine to encorafenib and cetuximab in patients with metastatic BRAF V600E colon cancer with…
Read article →CHCHD2 and CHCHD10 promoted autophagic clearance of protein aggregates via GABARAPs
Mutations in mitochondrial protein CHCHD2 and its paralog CHCHD10 were identified in patients with Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), frontotemporal…
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Mammalian Lysophagy: mechanisms and pathophysiological implications
Lysophagy is a form of selective macroautophagy/autophagy that preserves lysosomal integrity by eliminating damaged lysosomes. Lysosomal membrane permeabilization can arise from…
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Metformin-phytochemical combination therapy in metabolic dysfunction-associated steatotic liver disease: mechanistic insights and therapeutic potential
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial metabolic disorder characterized by excessive hepatic lipid accumulation, insulin resistance,…
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