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2-TIP QANDLI DIABET PATOGENEZIDA AUTOFAGIYA JARAYONINING ROLI VA INTERVAL OCHLIKNING BIOKIMYOVIY KORREKSIYASI

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Editor's note
Blocking the mTOR pathway during fasting may restore a critical cellular cleanup process that fails in type 2 diabetes, potentially offering a non-pharmacological route to disease remission. This work bridges emerging mechanistic understanding of autophagy's role in insulin resistance with a testable clinical intervention, positioning fasting as metabolically corrective rather than restrictive. Endocrinologists, metabolic researchers, and diabetes specialists should assess whether these findings hold across larger populations.

Source: openalex · Ravshanoy Tursunova, Surayyo Boltayeva · Zenodo (CERN European Organization for Nuclear Research) · 2026-05-25

URL: https://doi.org/10.5281/zenodo.20378190

AI rationale (4/5, tier: emerging): Directly addresses autophagy blockade in T2DM via mTOR/AMPK signalling and fasting-induced autophagy flux; human intervention study.

Dunyo miqyosida 2-tip qandli diabet (T2DM) patogenezida hujayra darajasidagi metabolik disfunksiya asosiy omil bo‘lib qolmoqda. Ushbu maqolada surunkali giperinsulinemiya sharoitida mTOR signal yo‘lining o‘ta faollashuvi natijasida autofagiya jarayonining bloklanishi tahlil qilinadi. Tadqiqot interval ochlik (16:8) rejimi orqali AMPK oqsilini faollashtirish va "metabolik kalit" mexanizmini ishga tushirish imkoniyatlarini ko‘rib chiqadi. Ma’lumotlar shuni ko‘rsatadiki, 16–18 soatlik ochlik beta-hujayralardagi amiloid agregatlarini parchalash orqali insulin rezistentligini biokimyoviy korreksiya qiladi. Olingan natijalar T2DM nazoratida farmakologik yuklamani kamaytirish va kasallik remissiyasiga erishishda sitotsentrik yondashuvning afzalliklarini asoslab beradi

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Published 2026-05-28 · Last kit-update 2026-05-28