Chronic inflammation
Inflammaging — when the alarm never stops
Acute inflammation is a feature, chronic inflammation is a bug. This topic curates the evidence on the slow-burn inflammation that links obesity to cancer, aging to dementia, and stress to autoimmunity.
Anti-inflammatory effects of oral NLRP3 inhibition with ruvonoflast among individuals at elevated cardiovascular risk
The NLRP3 inflammasome is a key sensor of diverse exogenous stimuli linked to non-communicable diseases including atherosclerotic cardiovascular disease. Early clinical data with the oral NLRP3 inhibitor ruvonoflast suggested lowering of biomarkers of systemic and central nervous system inflammation. To assess anti-inflammatory efficacy and safety of ruvonoflast in…
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5 articles in Chronic inflammation, sorted by date
Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis
Introduction Aging impairs immunity, sustains chronic inflammation, and enhances autoimmunity–a process termed “immunosenescence” that contributes to the pathogenesis of type 2…
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Effect of methotrexate on endothelial function in psoriasis patients
INTRODUCTION: Psoriasis is a chronic immune-mediated inflammatory dermatosis associated with systemic comorbidities, including metabolic disorders, atherosclerosis, and increased…
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Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV
This is a prospective cohort study of 12 overweight (with one or more weight-related condition) or obese adults with well controlled HIV-1 on antiretroviral therapy (ART). An…
Read article →1,25-Dihydroxyvitamin D3 mitigates high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in glomerular mesangial cells via the ROS/TXNIP/NLRP3 pathway
BACKGROUND: in diabetic nephropathy (DN) progression and its underlying mechanism targeting the ROS/TXNIP/NLRP3 inflammasome pathway. METHODS: (1-50 nM), or high glucose plus…
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