Chronic inflammation
Inflammaging — when the alarm never stops
Acute inflammation is a feature, chronic inflammation is a bug. This topic curates the evidence on the slow-burn inflammation that links obesity to cancer, aging to dementia, and stress to autoimmunity.
Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis
Introduction Aging impairs immunity, sustains chronic inflammation, and enhances autoimmunity–a process termed “immunosenescence” that contributes to the pathogenesis of type 2 diabetes and rheumatoid arthritis (RA). Post-pubertal thymic involution depletes naïve T-cell pool, promoting the emergence of senescent CD4 + T cells. To maintain T-cell homeostasis, these cells…
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3 articles in Chronic inflammation tagged Speculation, sorted by date
Effect of methotrexate on endothelial function in psoriasis patients
INTRODUCTION: Psoriasis is a chronic immune-mediated inflammatory dermatosis associated with systemic comorbidities, including metabolic disorders, atherosclerosis, and increased…
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1,25-Dihydroxyvitamin D3 mitigates high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in glomerular mesangial cells via the ROS/TXNIP/NLRP3 pathway
BACKGROUND: in diabetic nephropathy (DN) progression and its underlying mechanism targeting the ROS/TXNIP/NLRP3 inflammasome pathway. METHODS: (1-50 nM), or high glucose plus…
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