Mitochondrial biology
Cellular energy, repair, and the second genome
Mitochondria are not just power plants. They are signalling organelles, fate-decision centres, and the carrier of an independent genome. This topic curates the evidence on mitochondrial biology in health, aging, and disease.
Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer’s Disease: Mechanisms and Therapeutic Restoration
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22 articles in Mitochondrial biology, sorted by date
Transglutaminase and its role in Alzheimer's disease: focus on mitochondria, aging, defective mitophagy, synaptic degeneration, and metabolomics
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline driven by amyloid-β plaques, tau neurofibrillary tangles,…
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Corrigendum to "JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy" [J Orthop Transl 51 (2025) 132-144 / doi: 10.1016/j.jot.2025.01.001]
Read article →Mitochondrial transfer: A comprehensive analysis of mechanistic insights, preclinical applications, and technological innovations
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Dexmedetomidine attenuates LPS-induced acute lung injury via activation of mitochondrial autophagy
This study aimed to examine the impact of Dex on ALI and clarify the mechanisms, particularly regarding mitophagy. The assignment of male Sprague–Dawley rats was random, with rats…
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Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging mice
Age-related diseases arise from prolonged exposure to genetic and/or environmental factors, ultimately leading to cumulative and irreversible degeneration of tissues and the…
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Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
<h4>Background</h4>Intracerebral hemorrhage complicated by diabetes mellitus (DM-ICH) is characterized by severe secondary injury of the blood-brain barrier (BBB) and poor…
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SIRT5-dependent desuccinylation licenses UBR5-mediated degradation of TAMM41 to regulate mitochondrial metabolism in lung adenocarcinoma
Mitochondrial metabolic reprogramming is essential for lung adenocarcinoma (LUAD) progression, yet the regulatory mechanisms governing mitochondrial phospholipid synthesis remain…
Read article →Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Numerous clinical studies…
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Diphlorethohydroxycarmalol isolated from <i>Ishige okamurae</i> improves age-related muscle dysfunction by Ca<sup>2+</sup>-dependent response <i>via</i> the SirT1/PGC-1α pathway <i>in vitro</i> and <i>i
Diphlorethohydroxycarmalol (DPHC), a brown alga tannin isolated from Ishige okamurae, has been reported to stimulate skeletal muscle contraction by promoting the release of…
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