Mitochondrial biology
Cellular energy, repair, and the second genome
Mitochondria are not just power plants. They are signalling organelles, fate-decision centres, and the carrier of an independent genome. This topic curates the evidence on mitochondrial biology in health, aging, and disease.
The Role of Mitochondria in Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a genetic disorder characterized by renal cyst formation and progressive renal dysfunction, where inflammation, immune responses, and metabolic dysregulation critically drive disease progression, while emerging evidence increasingly links its pathogenesis to mitochondrial dysfunction. Mitochondria, central to cellular energy production,…
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7 articles in Mitochondrial biology tagged Hypothesis, sorted by date
Mito_Plot: open-source pipeline for quantification and visualization of mitochondrial DNA heteroplasmy
<h4>Background</h4>Mitochondrial DNA heteroplasmy plays a crucial role in mitochondrial function, aging, and a wide range of human diseases. Recent advances in high-throughput…
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Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial
This phase II randomized control trial assesses the effect of Urolithin A (Uro-A) supplementation compared to placebo in men with biopsy-confirmed prostate cancer undergoing…
Read article →Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
The MIRACLE study aims to investigate age-related mitochondrial dysfunction, mitochondrial RNA (mtRNA) release, inflammation, and cellular senescence in adult participants across…
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Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer's Disease: Mechanisms and Therapeutic Restoration
Alzheimer's disease (AD) is characterized by early bioenergetic failure, contributing to synaptic dysfunction and neuronal vulnerability. This review examines a critical…
Read article →Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
Abstract Small extracellular vesicles (sEVs) orchestrate cell-cell communication, but the role of sEV signaling via mitochondria in perpetuating asthmatic airway inflammation is…
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NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells
The effect of NAD<sup>+</sup> in enhancing mitochondrial function and energy metabolism in human cells is closely linked to NAD<sup>+</sup>-dependent sirtuins (i.e. SIRT1 and…
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