Mitochondrial biology
Cellular energy, repair, and the second genome
Mitochondria are not just power plants. They are signalling organelles, fate-decision centres, and the carrier of an independent genome. This topic curates the evidence on mitochondrial biology in health, aging, and disease.
Dexmedetomidine attenuates LPS-induced acute lung injury via activation of mitochondrial autophagy
This study aimed to examine the impact of Dex on ALI and clarify the mechanisms, particularly regarding mitophagy. The assignment of male Sprague–Dawley rats was random, with rats going to the control, LPS, and LPS + Dex groups. In vitro, the NR8383 rat alveolar macrophage cell line was treated with LPS and Dex. Techniques such as ELISA, lung wet-to-dry ratio measurement,…
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11 articles in Mitochondrial biology tagged Speculation, sorted by date
Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging mice
Age-related diseases arise from prolonged exposure to genetic and/or environmental factors, ultimately leading to cumulative and irreversible degeneration of tissues and the…
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Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
<h4>Background</h4>Intracerebral hemorrhage complicated by diabetes mellitus (DM-ICH) is characterized by severe secondary injury of the blood-brain barrier (BBB) and poor…
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SIRT5-dependent desuccinylation licenses UBR5-mediated degradation of TAMM41 to regulate mitochondrial metabolism in lung adenocarcinoma
Mitochondrial metabolic reprogramming is essential for lung adenocarcinoma (LUAD) progression, yet the regulatory mechanisms governing mitochondrial phospholipid synthesis remain…
Read article →Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by persistent synovial inflammation and progressive joint destruction. Numerous clinical studies…
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Diphlorethohydroxycarmalol isolated from <i>Ishige okamurae</i> improves age-related muscle dysfunction by Ca<sup>2+</sup>-dependent response <i>via</i> the SirT1/PGC-1α pathway <i>in vitro</i> and <i>i
Diphlorethohydroxycarmalol (DPHC), a brown alga tannin isolated from <i>Ishige okamurae</i>, has been reported to stimulate skeletal muscle contraction by promoting the release of…
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Cardiomyocyte BMAL1 deficiency worsens obesity-related cardiomyopathy with heightened PINK1/Parkin-linked mitophagy and mitochondrial dysfunction
Obesity-related cardiomyopathy (OCM) is characterized by pathological cardiac remodeling and progressive functional decline, often accompanied by mitochondrial dysfunction,…
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Heterogeneous Mitochondrial Gene Expression in SH-SY5Y Cells Following ERRa and ERRy Depletion Reveals Divergent Stress Responses
<title>Abstract</title> <p>Mitochondrial dysfunction is implicated in neurodegenerative and neuropsychiatric disorders, yet the transcriptional mechanisms governing mitochondrial…
Read article →Hirudin Promotes Peripheral Nerve Repair by Enhancing Mitophagy to Suppress NLRP3 Inflammasome Activation
<title>Abstract</title> <p> <bold>Background</bold> : Peripheral nerve injuries cause major functional deficits and have few pharmacological options. We evaluated whether hirudin…
Read article →Inhibition of Mitochondrial Respiration Fragments ER Architecture and Remodels Organelle Contact Sites, as Revealed by FIB-SEM
The endoplasmic reticulum (ER) and mitochondria maintain a dynamic structural partnership essential for pancreatic beta-cell homeostasis, yet the high-resolution 3D remodeling of…
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