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Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity

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Source: [ctgov](https://clinicaltrials.gov/study/NCT07589647)

Authors: First Affiliated Hospital of Zhejiang University

Venue: RECRUITING · 2026-05-27

Abstract

This study aims to stabilize the patients with bipolar disorder (BD) comorbid with obesity in the stable phase by using temporal interference stimulation (TIS ) intervention. It intends to investigate the changes in key metabolic molecules such as GLP-1 circadian rhythm, and further explore the molecular mechanism of their metabolic disorders.

AI relevance (4/5): Directly targets suprachiasmatic nucleus circadian function via novel intervention (TIS) with mechanistic readouts (GLP-1 rhythm, metabolic molecules) in human subjects; interventional RCT design aligns with brief priorities, though recruiting status limits current evidence strength.

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Published 2026-05-29 · Last kit-update 2026-05-28