Mucosa
The body's most consequential interface
Mucosa is where tissue meets world. Many of medicine's hardest questions still lie open here — barrier dysfunction, microbiome-host signalling, resolution biology. This topic curates the current evidence with citation rigor.
Anti-inflammatory and gut microbiota-modulating effects of a novel mannan from Scilla scilloides on DSS-induced colitis in mice
Scilla scilloides is a traditional plant with medicinal and nutritional value, known for its diverse biological activities. This study aimed to identify the structure of a novel polysaccharide SCSP-W from Scilla scilloides and evaluate its anti-colitis activity. SCSP-W is primarily composed of mannose, rhamnose, galacturonic acid, galactose, and arabinose in a molar ratio of…
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6 articles in Mucosa tagged Speculation, sorted by date
Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages
Background The pathogenesis of ulcerative colitis (UC) remains incompletely understood, and effective therapeutic targets are still lacking in clinical practice. Macrophage…
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Eubacterium rectale Mitigates Inflammatory Bowel Disease via Modulation of Glutamine Metabolism Through the GLS2 and NF-κB Pathway
Inflammatory Bowel Disease (IBD) is a chronic inflammatory intestinal disorder with complex etiology, closely associated with gut microbiota dysbiosis. This study demonstrates…
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Yajieshaba extract improves alcohol‑induced liver injury by regulating hepatic lipid metabolism and gut microbiota
<h4>Background</h4>Yajieshaba, a commonly used Dai medicine formula, is renowned for its hepatoprotective properties. This study aimed to investigate the therapeutic effects and…
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Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
*Draft auto-created from Suggestions queue. Polish the body, set is_real=true when verified, and publish via `INSERT INTO bionoia_published` when ready for /public/.*
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The integrated mechanistic model
When all of this is integrated, a pattern emerges that may match many escalating mucosal-disease pictures. The primary lesion (hypothesis): defective mucin glycosylation — either…
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