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Mechanism of FODMAP Restriction on FGID Patients

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Editor's note
The mechanistic gaps in FODMAP efficacy remain largely unexplored—this trial directly addresses whether symptom relief stems from microbiota shifts, barrier restoration, or psychological factors, which could reshape dietary counseling beyond empirical trial-and-error. The evidence base here is sparse; mechanistic data comparing low-FODMAP variants is genuinely novel territory, though the findings will be incremental until replicated across populations. Gastroenterologists and dietitians managing functional bowel disorders should watch closely, as precision diet selection could reduce the current one-size-fits-some approach.

Source: ctgov · Universiti Kebangsaan Malaysia Medical Centre · RECRUITING · 2026-05-11

URL: https://clinicaltrials.gov/study/NCT07000227

AI rationale (4/5, tier: unclassified): Directly investigates gut barrier function and microbiota in FGID; mechanistic focus on diet-microbiome-barrier interactions.

Brief Summary :

The goal of this clinical trial is to investigate the effects of differing FODMAP diets on gut microbiota, gut barrier function, symptom severity, quality of life, and psychological status in FGID patients. The main question it aims to answer is :

How does diets with differing FODMAP content affect the gut microbiota, gut barrier function, symptom severity, psychological status and quality of life in patients with FGID ? Researchers will compare low FODMAP diet, Gentle FODMAP diet and Traditional Dietary Advice (NICE guidelines) to see which diet is more suitable and effective for Malaysian FGID patients.

Participants will :

Be given either low FODMAP diet, Gentle FODMAP diet or Traditional Dietary Advice intervention and will be required to follow the intervention for two weeks.

Be required to provide stool and blood samples during baseline and intervention Record 4 day food diary and complete assessing questionnaires during baseline and intervention

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Published 2026-05-28 · Last kit-update 2026-05-28