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All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.
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Evidence tier
22 articles of 156
Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer’s Disease: Mechanisms and Therapeutic Restoration
Mitochondrial biology · Discovery ·
**Source:** [openalex](https://doi.org/10.1007/s12031-026-02531-y)
**Authors:** Ahmed M Abdelaziz, Mustafa M Shokr, Mohamed K. Fathy, Mohamed N Fawzy
**Venue:** Journal of Molecu…
Transglutaminase and its role in Alzheimer's disease: focus on mitochondria, aging, defective mitophagy, synaptic degeneration, and metabolomics
Mitochondrial biology · Discovery ·
**Source:** [europepmc](https://pubmed.ncbi.nlm.nih.gov/42185591/)
**Authors:** Hiruthyaswamy SP, Rao D, Balakrishna S, Macarius NMN, Sakthivel YK, Deepankumar K, Vijayan M.
**Ve…
Corrigendum to "JP4-039 protects chondrocytes from ferroptosis to attenuate osteoarthritis progression by promoting Pink1/Parkin-dependent mitophagy" [J Orthop Transl 51 (2025) 132-144 / doi: 10.1016/j.jot.2025.01.001]
Mitochondrial biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42199805/)
**Authors:** Xie Y, Lv Z, Li W, Lin J, Sun W
**Venue:** J Orthop Translat · 2026 Jul
**AI relevance (5/5):** Dir…
Mitochondrial transfer: A comprehensive analysis of mechanistic insights, preclinical applications, and technological innovations
Mitochondrial biology · Discovery ·
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42199126/)
**Authors:** Wang Y, Wang Z, Zhao J, Zhou Y, Wei D
**Venue:** Neural Regen Res · 2026 May 14
**AI relevance (5/5…
Dexmedetomidine attenuates LPS-induced acute lung injury via activation of mitochondrial autophagy
SpeculationMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Huaixin Xing, Yan Ma, Xiangzhen Min, Yingui Sun, Guanrong Li · European journal of medical research · 2026-05-26
**URL:** https://d…
Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging mice
SpeculationMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **FR** · Márcio A. C. Ribeiro, Vanessa Morais Lima, Thiago N. Menezes, Wenjin Yang, Juliane C. Campos · bioRxiv (Cold Spring Harbor Laboratory)…
Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Wang Y, Kuang B, Chen Y, Zou W, Zheng L, Zhang B, Shang T, Xu C, Xu Q, Li H, Hu Y, Zhao K, Kuang H. · Journal of neuroinflammation ·…
SIRT5-dependent desuccinylation licenses UBR5-mediated degradation of TAMM41 to regulate mitochondrial metabolism in lung adenocarcinoma
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Yuan H, Hu W, Lv X, Cao Y, Hu K, Li Y, Chen Z, Yang J, Wang Y, Zhao J, Xu C. · Biology direct · 2026-05-25
**URL:** https://pubmed…
Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Wu Y, Fu T, Teng Y, Pan Y, Li L, Feng Y, Lin J. · Autophagy · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.nih.gov/42186185/
**AI …
Diphlorethohydroxycarmalol isolated from <i>Ishige okamurae</i> improves age-related muscle dysfunction by Ca<sup>2+</sup>-dependent response <i>via</i> the SirT1/PGC-1α pathway <i>in vitro</i> and <i>i
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **KR** · Wang X, Kim CY, Je JG, Roh YJ, Yang F, Yang HW, Jeon YJ. · Food & function · 2026-05-26
**URL:** https://pubmed.ncbi.nlm.nih.gov/4…
Cardiomyocyte BMAL1 deficiency worsens obesity-related cardiomyopathy with heightened PINK1/Parkin-linked mitophagy and mitochondrial dysfunction
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu T, Fan X, Zhang N, Wang Y, Qian Z, Hou X, Zhang H, Zou J. · Journal of biomedical research · 2026-05-25
**URL:** https://pubme…
Heterogeneous Mitochondrial Gene Expression in SH-SY5Y Cells Following ERRa and ERRy Depletion Reveals Divergent Stress Responses
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Mandel AR. · Research Square · 2026-05-25
**URL:** https://europepmc.org/article/PPR/PPR1237947
**AI rationale (4/5, tier: preliminary):** Mechanism…
Hirudin Promotes Peripheral Nerve Repair by Enhancing Mitophagy to Suppress NLRP3 Inflammasome Activation
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Yan R, Zhe Z, Zhang J, Lin T, Xiao S, Liu H, Mao H, Cooper T, Alqadhi S, Li B, Wu L. · Research Square · 2026-05-25
**URL:** https://europepmc.org/ar…
Inhibition of Mitochondrial Respiration Fragments ER Architecture and Remodels Organelle Contact Sites, as Revealed by FIB-SEM
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Dlaskova A, Bazila B, Krepelka P, Victor RC, Jhala DJ, Jezek P. · bioRxiv · 2026-05-25
**URL:** https://europepmc.org/article/PPR/PPR1238456
**AI ra…
Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
SpeculationMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Yue Wang, Binglin Kuang, Chen Yangwen, Wei Zou, Lei Zheng · Journal of Neuroinflammation · 2026-05-25
**URL:** https://doi.org/10.1…
The Role of Mitochondria in Polycystic Kidney Disease
HypothesisMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Yuhe Wang, Jianhua Mao, F Liu · International Journal of Molecular Sciences · 2026-05-26
**URL:** https://doi.org/10.3390/ijms27114…
Mito_Plot: open-source pipeline for quantification and visualization of mitochondrial DNA heteroplasmy
HypothesisMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **JP** · Nakamura K, Matsumoto N, Okazaki Y. · BMC bioinformatics · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.nih.gov/42185947/
**AI rat…
Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial
HypothesisMitochondrial biology · Discovery ·
**Source:** ctgov · National Cancer Institute (NCI) · RECRUITING · 2026-05-13
**URL:** https://clinicaltrials.gov/study/NCT06022822
**AI rationale (4/5, tier: emerging):** …
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
HypothesisMitochondrial biology · Discovery ·
**Source:** ctgov · Mario Negri Institute for Pharmacological Research · NOT_YET_RECRUITING · 2026-05-19
**URL:** https://clinicaltrials.gov/study/NCT07596615
**AI rational…
Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer's Disease: Mechanisms and Therapeutic Restoration
HypothesisMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **EG** · Abdelaziz AM, Shokr MM, Fathy MK, Fawzy MN. · Journal of molecular neuroscience : MN · 2026-05-25
**URL:** https://pubmed.ncbi.nlm…
Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
HypothesisMitochondrial biology · Discovery ·
**Source:** openalex · Kenneth P. Hough, Jennifer Trevor, Shaheer Ahmad, Yong Wang, Balu K. Chacko · Nature Communications · 2026-05-26
**URL:** https://doi.org/10.1038/s414…
NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells
HypothesisMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Cui J, Ren S, Wang B, Zhang N, Zhu S, Zhang Y, Qi X, Meng W, Shao L, Gao S, Xing L, Li Z, Mu X. · Autophagy · 2026-05-24
**URL:** …