Bionoia Where life meets thought ⌕
Back to Journal
Journal › Mucosa
Discovery

Gut Leakage' in Dengue

Read original paper
Editor's note
Dengue's progression to severe disease involves gastrointestinal symptoms that may signal barrier breakdown—a mechanism poorly understood but potentially central to mortality risk. This early-stage investigation directly addresses a gap between clinical observation and mechanistic understanding in a WHO-priority pathogen affecting millions annually. Infectious disease specialists, tropical medicine practitioners, and barrier biology researchers should track this work as it may reshape how we conceptualize dengue severity beyond viral load alone.

Source: ctgov · University of Oxford · NOT_YET_RECRUITING · 2026-05-22

URL: https://clinicaltrials.gov/study/NCT07602920

AI rationale (4/5, tier: unclassified): Directly addresses gut barrier dysfunction and permeability ('gut leakage') in disease context, core to corpus focus.

Dengue infections are imposing an increasing global burden of disease, particularly in tropical countries such as Bangladesh. The World Health Organization (WHO) has identified Dengue virus as a priority pathogen for the development of medical counter measures because of the high risk of it causing a Public Health Emergency of Intenational Concern (PHEIC). Warning signs for severe dengue, associated with mortality, include gastrointestinal features including abdominal pain, vomiting, and diarrhoea. Multiple alterations may occur in in the gastrointestinal tract that could lead to damaging of the gastrointestinal wall and gut leakage, the translocation of gut metabolites into the bloodstream. We hypothesize that gut leakage initiates inflammatory processes underlying the further development of severe dengue, including features associated with plasma leakage.

This study aims to investigate intestinal barrier dysfunction (gut leakage) in dengue infection by detecting the translocation of

Related articles in this corpus

Parallel
Saccharomyces Boulardii CNCM I-745 on Intestinal Barrier Function
Both articles address intestinal barrier dysfunction in disease contexts—Article A identifies gut leakage as a dengue complication while Article B evaluates a probiotic intervention for intestinal permeability impairment, representing related but non-overlapping approaches to the same pathophysiological problem.
Parallel
The Role of Vitamin D in Inflammatory Bowel Disease: Clinical Relevance and Therapeutic Potential
Both articles address gastrointestinal dysfunction in disease states, but Article A focuses on dengue-induced gut barrier breakdown as a severe complication while Article B examines vitamin D's role in maintaining intestinal barrier integrity in chronic IBD, with no direct mechanistic or therapeutic overlap.
Parallel
Gut microbiome-mediated bioactive ingredients and health benefits of medicinal and edible fermented products: A comprehensive review
Both articles address gut health outcomes but from opposing perspectives: Article A examines pathological gut dysfunction in dengue infection, while Article B explores therapeutic gut microbiome modulation through fermented products, with no direct evidence that one addresses or builds upon the other's findings.
Published 2026-05-28 · Last kit-update 2026-05-28