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Mucosa · Discovery ·

**Source:** openalex · Origin: **RO** · Caterina Dumitru, Alina Oana Dumitru, Larisa Goroftei, Elena Niculeț, Mariana Daniela Ignat · Pharmaceutics · 2026-05-26 **URL:** h…

Mucosa · Discovery ·

**Source:** openalex · Philippe Attieh, Dana Dabboussi, Wael Meraabi, Karam Karam, Rose Raymond Al Bacha · World Journal of Gastrointestinal Pharmacology and Therapeutics · 2…

Mucosa · Architecture · mechanism_review

**Summary** The intestinal mucus barrier is more complex than commonly described. In the colon, there are two mucin layers: an inner, dense, sterile layer firmly attached to the e…

Mucosa · Architecture · mechanism_review

**Summary** MUC2 — the dominant secreted mucin in the colon — is not protein with sugar attached. It is, by weight, mostly sugar. Up to eighty percent of the molecule's mass is it…

Mucosa · Genetic factors · mechanism_review

**Summary** The FUT2 (Secretor) gene encodes an α-1,2-fucosyltransferase responsible for expressing ABO histo-blood group antigens on gastrointestinal mucosa and in bodily secreti…

Mucosa · Adjacent systems · mechanism_review

**Summary** Conceptually one of the most important paradigm shifts in inflammation research in the past 15 years, led by Charles Serhan at Harvard. Resolution of inflammation is n…

Mucosa · Mechanisms of dysfunction · mechanism_review

"Leaky gut → sepsis" is not a one-way mechanism. It is a self-reinforcing cycle. Both leaky gut (barrier defect at intestinal surface) and gut dysbiosis are intrinsic to sepsis. W…

Mucosa · Mechanisms of dysfunction · mechanism_review

Patients with SIBO have significantly lower ileocecal pressure thresholds, prolonged small bowel transit time, and higher gastrointestinal pH compared to those without SIBO. The s…

Mucosa · Microbiome interface · mechanism_review

Goblet cells and colonocytes run on butyrate as primary energy source. This is not incidental. Butyrate serves as a key energy substrate for goblet cells producing MUC2 and protec…

Mucosa · Microbiome interface · mechanism_review

Akkermansia muciniphila colonizes the mucosal layer of the human gut. It is particularly effective at increasing mucus thickness and improving barrier function. A. muciniphila rest…

Mucosa · Microbiome interface · mechanism_review

Bile acids are not just fat emulsifiers. They are signaling molecules. The intestinal epithelium prominently expresses two key bile acid receptors — farnesoid X receptor (FXR) and…

Mucosa · Architecture · mechanism_review

The small intestine has its own specialized defense system: Paneth cells at the bottom of the crypts of Lieberkühn, which produce potent antimicrobial peptides — particularly HD5 a…

Mucosa · Adjacent systems · human_observational

Mast cell activation syndrome (MCAS) is a differential consideration in any picture combining inflammation escalation, mucus hypersecretion, and food intolerance patterns. Mast ce…

Mucosa · Adjacent systems · mixed

The vagus nerve has anti-inflammatory properties through its afferents (activating HPA) and its efferents (the cholinergic anti-inflammatory pathway, CAP). The CAP inhibits pro-inf…

Mucosa · Architecture · mechanism_review

A third barrier system, often overlooked in clinical discussion: the glycocalyx layer on the basolateral side of enterocytes, primarily based on heparan sulfate proteoglycans (espe…

Mucosa · Architecture · mechanism_review

If SCFAs fuel the goblet cells, trefoil factors are the active repair signal. These small peptides are underappreciated and directly relevant. Trefoil peptides play important role…

Mucosa · Interventions · mixed

Specific food additives have surprisingly strong evidence for mucus barrier damage. Consumption of generally-regarded-as-safe emulsifiers has increased, and is associated with inc…