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All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.
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Evidence tier
65 articles of 156
Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV
HypothesisChronic inflammation · Discovery ·
**Source:** ctgov · University of Hawaii · RECRUITING · 2026-05-27
**URL:** https://clinicaltrials.gov/study/NCT06935838
**AI rationale (4/5, tier: emerging):** Prospective…
The Role of Mitochondria in Polycystic Kidney Disease
HypothesisMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Yuhe Wang, Jianhua Mao, F Liu · International Journal of Molecular Sciences · 2026-05-26
**URL:** https://doi.org/10.3390/ijms27114…
Microbiota remodeling after bariatric surgery: Procedure-specific dynamics and metabolic implications
HypothesisMicrobiome ecology · Discovery ·
**Source:** openalex · Zhi-Jie Qu, Shan Cong, Yang Cong, Yan Jiao, Ya-Hui Liu · World Journal of Gastrointestinal Surgery · 2026-05-27
**URL:** https://doi.org/10.4240/wjgs.…
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer
HypothesisMicrobiome ecology · Discovery ·
**Source:** ctgov · University of Illinois at Chicago · COMPLETED · 2026-05-27
**URL:** https://clinicaltrials.gov/study/NCT04753359
**AI rationale (4/5, tier: emerging):**…
Gut Microbiome in AP Naive
HypothesisMicrobiome ecology · Discovery ·
**Source:** ctgov · Centre for Addiction and Mental Health · ACTIVE_NOT_RECRUITING · 2026-05-27
**URL:** https://clinicaltrials.gov/study/NCT03414151
**AI rationale (4/5, t…
Influence of Probiotics on Early Gut Microbial Colonization
HypothesisMicrobiome ecology · Discovery ·
**Source:** ctgov · BioGaia AB · NOT_YET_RECRUITING · 2026-05-27
**URL:** https://clinicaltrials.gov/study/NCT07608341
**AI rationale (4/5, tier: emerging):** RCT of probio…
The Effect of OptiFibre Dietary Fiber on Carbohydrate Metabolism and Intestinal Microbiota Metabolism in Patients With Type 2 Diabetes Mellitus
HypothesisMicrobiome ecology · Discovery ·
**Source:** ctgov · Pirogov Russian National Research Medical University · COMPLETED · 2026-05-27
**URL:** https://clinicaltrials.gov/study/NCT07609992
**AI rationale (4/5,…
Comprehensive analysis of efferocytosis-related genes in diagnosis and immune infiltration in atherosclerosis: based on bulk and single-cell RNA sequencing data
HypothesisResolution biology · Discovery ·
**Source:** openalex · Origin: **CN** · Jintao Qian, Junhao Zhang, Yì Wáng, Suyu Xu, Li Y · Frontiers in Cell and Developmental Biology · 2026-05-26
**URL:** https://doi.o…
Pharmacomicrobiomics of Non-Antibiotic Drugs: Mechanisms and Clinical Consequences of Gut Microbiota Alterations
HypothesisMucosa · Discovery ·
**Source:** openalex · Origin: **RO** · Caterina Dumitru, Alina Oana Dumitru, Larisa Goroftei, Elena Niculeț, Mariana Daniela Ignat · Pharmaceutics · 2026-05-26
**URL:** h…
Beyond intestinal failure: Expanding therapeutic frontiers of glucagon-like peptide-2 in gastrointestinal disease
HypothesisMucosa · Discovery ·
**Source:** openalex · Philippe Attieh, Dana Dabboussi, Wael Meraabi, Karam Karam, Rose Raymond Al Bacha · World Journal of Gastrointestinal Pharmacology and Therapeutics · 2…
Irisin-integrin αV/β5 coupling of α-synuclein phagocytosis and clearance
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu Y, Shi S, Zhang J, Huang M, Wang M, Zhang T, Wang W, Xiang J. · Journal of neuroinflammation · 2026-05-26
**URL:** https://pub…
FOXO transcription factors in Alzheimer's Disease: balancing neuroprotection and neuronal degeneration
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **IN** · Shyam M, Veronica A, Wadhwa J, Sharma V, B M O, Srirangan P, Venkatesh R, Evan Prince S. · Molecular biology reports · 2026-05-26
…
Distinct psychophysiological biomarkers and risk stratification models for irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D)
HypothesisStress biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Chen X, Wang Y, Hou Y, Zhang L, Wu K, Wang C. · Scientific reports · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.nih.gov/42185404/…
Repeated whole-body cryostimulation promotes a blood pressure reduction at rest in healthy adult men
HypothesisStress biology · Discovery ·
**Source:** europepmc · Origin: **FR** · Jdidi H, de Bisschop C, Dugué B, Douzi W. · European journal of applied physiology · 2026-05-26
**URL:** https://pubmed.ncbi.nlm.n…
Mito_Plot: open-source pipeline for quantification and visualization of mitochondrial DNA heteroplasmy
HypothesisMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **JP** · Nakamura K, Matsumoto N, Okazaki Y. · BMC bioinformatics · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.nih.gov/42185947/
**AI rat…
Antimicrobial resistance and the human gut microbiome-a food safety perspective
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Origin: **IT** · Diaz-Amigo C, Bartolomé Del Pino LE, Lejeune J, Pinto Ferreira J, Bessy C. · Critical reviews in food science and nutrition · 2026-…
Integrated gut microbiota and metabolome signatures revealed by deep metagenomic sequencing in post-stroke cognitive impairment with type 2 diabetes
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu X, Kwok L-Y, Zhang W. · Microbiology spectrum · 2026-05-26
**URL:** https://pubmed.ncbi.nlm.nih.gov/42187250/
**AI rationale …
Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes by Targeting PF4<sup>+</sup> Macrophages in Acute Pancreatitis
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu L, Li G, Lu D, Ding H, Lu T, Sui Y, Zhang C, Xie Y, Kong R, Chen H, Bai X, Tan H, Xue D, Meng X, Li L, Sun B. · Advanced science …
Enterotype-specific microbial biomarkers of immune checkpoint inhibitor response revealed by large-scale integrated metagenomic analysis
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Origin: **IT** · Candeliere F, Busi E, Cerri S, Sola L, Lombardi M, Greco S, Pedroni S, Amaretti A, Raimondi S, Chiavelli C, Vitale MG, B · Cancer imm…
Effects of processed low-protein brown rice on patients with chronic kidney disease
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Origin: **JP** · Adachi K, Yasuda M, Ida M, Oshima Y, Azegami T, Yoshifuji A, Osada R, Oki I, Irie J, Kanda T, Takemura R, Hayashi K, Wak · Clinical a…
2-TIP QANDLI DIABET PATOGENEZIDA AUTOFAGIYA JARAYONINING ROLI VA INTERVAL OCHLIKNING BIOKIMYOVIY KORREKSIYASI
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** openalex · Ravshanoy Tursunova, Surayyo Boltayeva · Zenodo (CERN European Organization for Nuclear Research) · 2026-05-25
**URL:** https://doi.org/10.5281/zenodo…
Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** ctgov · Rapamycin Holdings Inc. · RECRUITING · 2026-05-22
**URL:** https://clinicaltrials.gov/study/NCT06950385
**AI rationale (4/5, tier: emerging):** Phase 3 …
Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** ctgov · Northwestern University · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT05576896
**AI rationale (4/5, tier: emerging):** Phase II…
Impact of Periodontal Inflammation on Allostatic Load
HypothesisStress biology · Discovery ·
**Source:** ctgov · Postgraduate Institute of Dental Sciences Rohtak · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT06978712
**AI rationale (4/5, ti…
The Effect of Physiotherapy Integrated With Yoga and Mindfulness on Individuals With Fibromyalgia
HypothesisStress biology · Discovery ·
**Source:** ctgov · University Hospital Tuebingen · ACTIVE_NOT_RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT07145788
**AI rationale (4/5, tier: emer…
Obstructive Sleep Apnoea and Difficult Asthma (OSADA)
HypothesisSleep biology · Discovery ·
**Source:** ctgov · St. James's Hospital, Ireland · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT07160868
**AI rationale (4/5, tier: emerging):** RC…
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
HypothesisSleep biology · Discovery ·
**Source:** ctgov · VA Office of Research and Development · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT02703207
**AI rationale (4/5, tier: emergin…
Population Based Lighting Study on Older Adults
HypothesisSleep biology · Discovery ·
**Source:** ctgov · Azienda Usl di Bologna · COMPLETED · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT05676086
**AI rationale (4/5, tier: emerging):** Light-dark…
Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial
HypothesisMitochondrial biology · Discovery ·
**Source:** ctgov · National Cancer Institute (NCI) · RECRUITING · 2026-05-13
**URL:** https://clinicaltrials.gov/study/NCT06022822
**AI rationale (4/5, tier: emerging):** …
Mitigating Mitochondrial RNA Release During Aging to Control Inflammation and Senescence
HypothesisMitochondrial biology · Discovery ·
**Source:** ctgov · Mario Negri Institute for Pharmacological Research · NOT_YET_RECRUITING · 2026-05-19
**URL:** https://clinicaltrials.gov/study/NCT07596615
**AI rational…
The human microbiome at translational crossroads: an ecological and causal perspective
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Origin: **SG** · Wong SH. · Singapore medical journal · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.nih.gov/42184295/
**AI rationale (4/5, tier: e…
Letter to the Editor: Gut microbiota–bile acid crosstalk - Prevotellaceae NK3B31 and 7-ketolithocholic acid drive metabolic benefits of distal bowel resection with preservation of terminal ileum
HypothesisMicrobiome ecology · Discovery ·
**Source:** openalex · Xu Cui, Long-Yao Xu, Bing-Qian Yin, liu chen, Zheng Liang · World Journal of Hepatology · 2026-05-26
**URL:** https://doi.org/10.4254/wjh.v18.i5.11551…
Westlake Frequent-sampling Cohort 2
HypothesisMicrobiome ecology · Discovery ·
**Source:** ctgov · Westlake University · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT07606885
**AI rationale (4/5, tier: emerging):** Longitudinal…
Psyllium in Pediatric IBS
HypothesisMicrobiome ecology · Discovery ·
**Source:** ctgov · Dr Bruno Chumpitazi, M.D. · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT06639984
**AI rationale (4/5, tier: emerging):** RCT me…
A single-strain dropout screen reveals mechanistic links between microbial ecology and metabolism
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Zeng X, Meng X, Weakley AM, Higginbottom SK, Lopez EM, Cabrera AV, Gray I, DeFelice B, Terasaki M, Zhao A, Hall KR, Levi · bioRxiv · 2026-05-25
**URL…
Schistosoma mansoni infection is associated with changes in gut microbiota in preschool age children in Albertine Region, Uganda
HypothesisMicrobiome ecology · Discovery ·
**Source:** europepmc · Edielu A, Lo C, Mawa PA, Webb EL, Elliott AM, Mugerwa JK, Oduru G, Nassuuna J, Ayebazibwe GK, Struebig M, Friedman JF, B · Research Square · 2026-05-2…
Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer's Disease: Mechanisms and Therapeutic Restoration
HypothesisMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **EG** · Abdelaziz AM, Shokr MM, Fathy MK, Fawzy MN. · Journal of molecular neuroscience : MN · 2026-05-25
**URL:** https://pubmed.ncbi.nlm…
Small extracellular vesicle signaling and mitochondrial transfer reprogram T helper cell function in human asthma
HypothesisMitochondrial biology · Discovery ·
**Source:** openalex · Kenneth P. Hough, Jennifer Trevor, Shaheer Ahmad, Yong Wang, Balu K. Chacko · Nature Communications · 2026-05-26
**URL:** https://doi.org/10.1038/s414…
NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells
HypothesisMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Cui J, Ren S, Wang B, Zhang N, Zhu S, Zhang Y, Qi X, Meng W, Shao L, Gao S, Xing L, Li Z, Mu X. · Autophagy · 2026-05-24
**URL:** …
dlmoR: An open-source R package for the dim-light melatonin onset (DLMO) hockey-stick method
HypothesisSleep biology · Discovery ·
**Source:** openalex · S. ; https://orcid.org/0009-0002-7320-9289 Thalji, M. ; https://orcid.org/0000-0002-8572-9268 Spitschan · MPG.PuRe (Max Planck Society) · 2026-06-01
*…
Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep
HypothesisSleep biology · Discovery ·
**Source:** ctgov · Hospices Civils de Lyon · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT07605858
**AI rationale (4/5, tier: emerging):** Sleep fr…
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
HypothesisSleep biology · Discovery ·
**Source:** ctgov · University of California, San Diego · RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT06548191
**AI rationale (4/5, tier: emerging)…
The Impacts of Trauma Exposure on Emotion Regulation and 2 Vagally Mediated Heart Rate Variability
HypothesisStress biology · Discovery ·
**Source:** openalex · Rebeka Catherine Tucker · CLOK (University of Central Lancashire) · 2027-01-01
**URL:** https://doi.org/10.17030/uclan.thesis.00059261
**AI rationale…
Distinct psychophysiological biomarkers and risk stratification models for irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D)
HypothesisStress biology · Discovery ·
**Source:** openalex · Origin: **CN** · X Chen, Yuxing Wang, Yanhong Hou, Li Zhang, Kai Wu · Scientific Reports · 2026-05-25
**URL:** https://doi.org/10.1038/s41598-026-50…
TREATMENT WITH MANDIBULAR ADVANCEMENT DEVICES IN COMORBID INSOMNIA AND SLEEP APNEA
HypothesisStress biology · Discovery ·
**Source:** openalex · Origin: **BR** · Lílian Chrystiane Giannasi, D Gozal, Luís Vicente Franco Vilela, Marco Antônio Cardoso Machado, Mônica Fernandes Gomes · InterAmerican…
CHCHD2 and CHCHD10 promoted autophagic clearance of protein aggregates via GABARAPs
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **SG** · Wei Z, Zhang M, Tang W, Singh BK, Zhiwei Z, Lei Z, Goh Kim Wee J, Tan Rui En F, Jingxiu H, Qiaoyang S, Bin X, Priyanka G · Autophagy …
Mammalian Lysophagy: mechanisms and pathophysiological implications
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **CN** · Ji F, Dai M, Wang Z, Dai E, Kang R, Klionsky DJ, Tang D, Huang Y, Sun Y, Tong L. · Autophagy · 2026-05-25
**URL:** https://pubmed.…
Metformin-phytochemical combination therapy in metabolic dysfunction-associated steatotic liver disease: mechanistic insights and therapeutic potential
HypothesisAutophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **IR** · Amri J, Karimpour A, Meshkani R. · Naunyn-Schmiedeberg's archives of pharmacology · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.ni…
Resolution as an active process
HypothesisResolution biology · Framework · mechanism_review
**Summary**
For decades inflammation was understood as a single process that simply "wore off" once the trigger was removed. Resolution was passive — what happened when nothing mo…
Specialized pro-resolving mediators (SPMs)
HypothesisResolution biology · Mediators · mechanism_review
**Summary**
SPMs are bioactive lipid metabolites derived from polyunsaturated fatty acids. They include four families: lipoxins (from arachidonic acid), E-series resolvins (from E…
The mucin barrier — architecture
HypothesisMucosa · Architecture · mechanism_review
**Summary**
The intestinal mucus barrier is more complex than commonly described. In the colon, there are two mucin layers: an inner, dense, sterile layer firmly attached to the e…
MUC2 glycosylation — the structural key
HypothesisMucosa · Architecture · mechanism_review
**Summary**
MUC2 — the dominant secreted mucin in the colon — is not protein with sugar attached. It is, by weight, mostly sugar. Up to eighty percent of the molecule's mass is it…
FUT2 secretor status — the testable genetic variable
HypothesisMucosa · Genetic factors · mechanism_review
**Summary**
The FUT2 (Secretor) gene encodes an α-1,2-fucosyltransferase responsible for expressing ABO histo-blood group antigens on gastrointestinal mucosa and in bodily secreti…
Resolution biology — SPMs (resolvins, protectins, maresins)
HypothesisMucosa · Adjacent systems · mechanism_review
**Summary**
Conceptually one of the most important paradigm shifts in inflammation research in the past 15 years, led by Charles Serhan at Harvard. Resolution of inflammation is n…
The sepsis-permeability feedback loop
HypothesisMucosa · Mechanisms of dysfunction · mechanism_review
"Leaky gut → sepsis" is not a one-way mechanism. It is a self-reinforcing cycle.
Both leaky gut (barrier defect at intestinal surface) and gut dysbiosis are intrinsic to sepsis. W…
Ileocecal vulnerability
HypothesisMucosa · Mechanisms of dysfunction · mechanism_review
Patients with SIBO have significantly lower ileocecal pressure thresholds, prolonged small bowel transit time, and higher gastrointestinal pH compared to those without SIBO.
The s…
Butyrate and SCFAs — the central fuel
HypothesisMucosa · Microbiome interface · mechanism_review
Goblet cells and colonocytes run on butyrate as primary energy source. This is not incidental.
Butyrate serves as a key energy substrate for goblet cells producing MUC2 and protec…
Akkermansia muciniphila and the mucolytic balance
HypothesisMucosa · Microbiome interface · mechanism_review
Akkermansia muciniphila colonizes the mucosal layer of the human gut. It is particularly effective at increasing mucus thickness and improving barrier function. A. muciniphila rest…
Bile acids as signaling molecules — FXR and TGR5
HypothesisMucosa · Microbiome interface · mechanism_review
Bile acids are not just fat emulsifiers. They are signaling molecules.
The intestinal epithelium prominently expresses two key bile acid receptors — farnesoid X receptor (FXR) and…
Paneth cells and α-defensins (HD5, HD6)
HypothesisMucosa · Architecture · mechanism_review
The small intestine has its own specialized defense system: Paneth cells at the bottom of the crypts of Lieberkühn, which produce potent antimicrobial peptides — particularly HD5 a…
Mast cells and mucus hypersecretion (MCAS)
HypothesisMucosa · Adjacent systems · human_observational
Mast cell activation syndrome (MCAS) is a differential consideration in any picture combining inflammation escalation, mucus hypersecretion, and food intolerance patterns.
Mast ce…
The vagus nerve and the cholinergic anti-inflammatory pathway
HypothesisMucosa · Adjacent systems · mixed
The vagus nerve has anti-inflammatory properties through its afferents (activating HPA) and its efferents (the cholinergic anti-inflammatory pathway, CAP). The CAP inhibits pro-inf…
The glycocalyx and heparan sulfate / syndecan-1
HypothesisMucosa · Architecture · mechanism_review
A third barrier system, often overlooked in clinical discussion: the glycocalyx layer on the basolateral side of enterocytes, primarily based on heparan sulfate proteoglycans (espe…
Trefoil factors (TFF1, TFF2, TFF3) — the active repair system
HypothesisMucosa · Architecture · mechanism_review
If SCFAs fuel the goblet cells, trefoil factors are the active repair signal. These small peptides are underappreciated and directly relevant.
Trefoil peptides play important role…
Dietary emulsifiers and mucus barrier damage
HypothesisMucosa · Interventions · mixed
Specific food additives have surprisingly strong evidence for mucus barrier damage.
Consumption of generally-regarded-as-safe emulsifiers has increased, and is associated with inc…