Browse
All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.
Topic
Evidence tier
30 articles of 156
Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis
SpeculationChronic inflammation · Discovery ·
**Source:** openalex · Origin: **JP** · J LI, Terukazu Sanui, Miyu Shida, Karen Yotsumoto, Mwannes Ahmad · Frontiers in Immunology · 2026-05-26
**URL:** https://doi.org/10…
Effect of methotrexate on endothelial function in psoriasis patients
SpeculationChronic inflammation · Discovery ·
**Source:** openalex · Origin: **BR** · Tiago Almeida Santos Costa, Isabella Bonilha, Sheila Tatsumi Kimura Medorima, Thiago Quinaglia Araújo Costa Silva, Simon · Journal of …
Dexmedetomidine attenuates LPS-induced acute lung injury via activation of mitochondrial autophagy
SpeculationMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Huaixin Xing, Yan Ma, Xiangzhen Min, Yingui Sun, Guanrong Li · European journal of medical research · 2026-05-26
**URL:** https://d…
Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging mice
SpeculationMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **FR** · Márcio A. C. Ribeiro, Vanessa Morais Lima, Thiago N. Menezes, Wenjin Yang, Juliane C. Campos · bioRxiv (Cold Spring Harbor Laboratory)…
Fecal Microbiota Transplant for Anorexia Nervosa
SpeculationMicrobiome ecology · Discovery ·
**Source:** ctgov · Hamilton Health Sciences Corporation · NOT_YET_RECRUITING · 2026-05-27
**URL:** https://clinicaltrials.gov/study/NCT06593366
**AI rationale (4/5, tier: …
Anti-inflammatory and gut microbiota-modulating effects of a novel mannan from Scilla scilloides on DSS-induced colitis in mice
SpeculationMucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Yuanhao Qiu, Zihan Liu, Weishuang Tong, Weiwei Fan, Aoying Zhang · Journal of Functional Foods · 2026-05-26
**URL:** https://doi.or…
Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages
SpeculationMucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Shenghao Xv, Jie Hao, Sanhua Deng, Zhengyin Zhang, Runshu Wang · Frontiers in Immunology · 2026-05-26
**URL:** https://doi.org/10.3…
Eubacterium rectale Mitigates Inflammatory Bowel Disease via Modulation of Glutamine Metabolism Through the GLS2 and NF-κB Pathway
SpeculationMucosa · Discovery ·
**Source:** openalex · Origin: **CN** · Lu Han, Yiyi Jin, Wen Lin, Zide Liu, Chunyan Zeng · npj Science of Food · 2026-05-26
**URL:** https://doi.org/10.1038/s41538-026-00…
Low-dimensional population dynamics in the brainstem gate REM sleep
SpeculationSleep biology · Discovery ·
**Source:** europepmc · Origin: **US** · Lozano DE, Hong J, Jin X, Stucynski JA, Machens CK, Chung S, Weber F. · Nature neuroscience · 2026-05-25
**URL:** https://pubmed.n…
Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Wang Y, Kuang B, Chen Y, Zou W, Zheng L, Zhang B, Shang T, Xu C, Xu Q, Li H, Hu Y, Zhao K, Kuang H. · Journal of neuroinflammation ·…
SIRT5-dependent desuccinylation licenses UBR5-mediated degradation of TAMM41 to regulate mitochondrial metabolism in lung adenocarcinoma
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Yuan H, Hu W, Lv X, Cao Y, Hu K, Li Y, Chen Z, Yang J, Wang Y, Zhao J, Xu C. · Biology direct · 2026-05-25
**URL:** https://pubmed…
Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Wu Y, Fu T, Teng Y, Pan Y, Li L, Feng Y, Lin J. · Autophagy · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.nih.gov/42186185/
**AI …
Diphlorethohydroxycarmalol isolated from <i>Ishige okamurae</i> improves age-related muscle dysfunction by Ca<sup>2+</sup>-dependent response <i>via</i> the SirT1/PGC-1α pathway <i>in vitro</i> and <i>i
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **KR** · Wang X, Kim CY, Je JG, Roh YJ, Yang F, Yang HW, Jeon YJ. · Food & function · 2026-05-26
**URL:** https://pubmed.ncbi.nlm.nih.gov/4…
Paeoniflorin Ameliorates Alcohol-Induced Depression via Modulating the Gut-Brain Axis and Inhibiting the NF-κB/NLRP3 Inflammasome Pathway in Mice
SpeculationMicrobiome ecology · Discovery ·
**Source:** europepmc · Origin: **CN** · Yu J, Zhang R, Quan Y, Sun D, Huang C, Xu J, Li X, Liu L. · Phytotherapy research : PTR · 2026-05-26
**URL:** https://pubmed.ncbi.…
Yajieshaba extract improves alcohol‑induced liver injury by regulating hepatic lipid metabolism and gut microbiota
SpeculationMucosa · Discovery ·
**Source:** europepmc · Origin: **CN** · Liping Y, Xingzhi Y, Jie T, Xiaohua D. · BMC complementary medicine and therapies · 2026-05-25
**URL:** https://pubmed.ncbi.nlm.ni…
Intermittent Theta-Burst Stimulation (iTBS) Improves Motor Coordination and Modulates Neuroinflammation and Autophagy in SCA3/MJD Mice
SpeculationAutophagy & cellular renewal · Discovery ·
**Source:** europepmc · Origin: **CN** · Chen LW, Lian YH, Dong XL, Luo KL, Zhan LQ, Xie LL, Sun QK, Lin W, Gan SR, Cheng XP, Ni J, Chen XY. · Cerebellum (London, England) ·…
MITF is essential for autophagy in the retinal pigment epithelium
SpeculationAutophagy & cellular renewal · Discovery ·
**Source:** europepmc · Garcia-Llorca A, Hermannsson K, Locri F, Andre H, Ogmundsdottir MH, Steingrimsson E, Eysteinsson T. · bioRxiv · 2026-05-25
**URL:** https://europepmc…
Regulatory impact of intermittent fasting on autophagy in high fat diet induced structural and cognitive brain deteriorations in rats
SpeculationAutophagy & cellular renewal · Discovery ·
**Source:** openalex · Mohamed Aref, Shimaa Hadhod, Nievin Ahmed Mahran, Haifa A. Alqahtani, Mohamed H. A. Gadelmawla · Scientific Reports · 2026-05-25
**URL:** https://doi.…
Impact of Chronic Mild Stress on Neurotrophic and Hypothalamic-Pituitary-Adrenal Factors in the Brain of Rats Submitted to Sepsis
SpeculationStress biology · Discovery ·
**Source:** europepmc · Origin: **BR** · Peper-Nascimento J, Possamai-Della T, Gois-Carvalho T, Aguiar-Geraldo JM, Pescador B, Quevedo J, Dal-Pizzol F, Valvassor · Neurotoxic…
Enhancing Slow Wave Sleep in Depression
SpeculationSleep biology · Discovery ·
**Source:** ctgov · Wake Forest University Health Sciences · NOT_YET_RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT07143838
**AI rationale (4/5, tier…
Sleep, Light, Circadian, Central Oxidative Stress
SpeculationSleep biology · Discovery ·
**Source:** ctgov · Brigham and Women's Hospital · NOT_YET_RECRUITING · 2026-05-26
**URL:** https://clinicaltrials.gov/study/NCT07471126
**AI rationale (4/5, tier: prelimin…
Cardiomyocyte BMAL1 deficiency worsens obesity-related cardiomyopathy with heightened PINK1/Parkin-linked mitophagy and mitochondrial dysfunction
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Origin: **CN** · Liu T, Fan X, Zhang N, Wang Y, Qian Z, Hou X, Zhang H, Zou J. · Journal of biomedical research · 2026-05-25
**URL:** https://pubme…
Heterogeneous Mitochondrial Gene Expression in SH-SY5Y Cells Following ERRa and ERRy Depletion Reveals Divergent Stress Responses
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Mandel AR. · Research Square · 2026-05-25
**URL:** https://europepmc.org/article/PPR/PPR1237947
**AI rationale (4/5, tier: preliminary):** Mechanism…
Hirudin Promotes Peripheral Nerve Repair by Enhancing Mitophagy to Suppress NLRP3 Inflammasome Activation
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Yan R, Zhe Z, Zhang J, Lin T, Xiao S, Liu H, Mao H, Cooper T, Alqadhi S, Li B, Wu L. · Research Square · 2026-05-25
**URL:** https://europepmc.org/ar…
Inhibition of Mitochondrial Respiration Fragments ER Architecture and Remodels Organelle Contact Sites, as Revealed by FIB-SEM
SpeculationMitochondrial biology · Discovery ·
**Source:** europepmc · Dlaskova A, Bazila B, Krepelka P, Victor RC, Jhala DJ, Jezek P. · bioRxiv · 2026-05-25
**URL:** https://europepmc.org/article/PPR/PPR1238456
**AI ra…
Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
SpeculationMitochondrial biology · Discovery ·
**Source:** openalex · Origin: **CN** · Yue Wang, Binglin Kuang, Chen Yangwen, Wei Zou, Lei Zheng · Journal of Neuroinflammation · 2026-05-25
**URL:** https://doi.org/10.1…
Gut Microbiota Dysbiosis Remodels the Multi-Tissue Transcriptional Landscape of the Host
SpeculationMicrobiome ecology · Discovery ·
**Source:** europepmc · Huang L, Liu S, Xiao S, Li Y, Luo S, Hou E, Wang Y, Zong X. · Research Square · 2026-05-25
**URL:** https://europepmc.org/article/PPR/PPR1238149
**A…
1,25-Dihydroxyvitamin D3 mitigates high glucose-induced oxidative stress, inflammation, and extracellular matrix accumulation in glomerular mesangial cells via the ROS/TXNIP/NLRP3 pathway
SpeculationChronic inflammation · Discovery ·
**Source:** openalex · Origin: **CN** · Qingyue Meng, Bo Chen, Chunjiang Zhang, Lin Jia, Xingyu Yao · PubMed · 2026-06-01
**URL:** https://doi.org/10.14670/hh-25-021
**AI…
Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
SpeculationMucosa · Discovery · animal
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42177552/)
**Authors:** Zou F, Wu Z, Wang S, Xu M, Xia P
**Venue:** J Transl Med · 2026 May 23
**AI relevance (5/5):** Dire…
The integrated mechanistic model
SpeculationMucosa · Synthesis · mechanism_review
When all of this is integrated, a pattern emerges that may match many escalating mucosal-disease pictures.
**The primary lesion (hypothesis):** defective mucin glycosylation — eit…