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Fecal Microbiota Transplant for Anorexia Nervosa

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Editor's note
Anorexia nervosa involves profound dysbiosis that may perpetuate both metabolic dysfunction and neuropsychiatric symptoms—making microbiome restoration a plausible therapeutic lever in a condition with few effective treatments. This pilot RCT sits at the exploratory edge of FMT science, testing whether engraftment can reverse disease-associated microbial depletion rather than treating established infection. Psychiatrists, eating disorder specialists, and microbiome researchers should watch for mechanistic data on the gut-brain axis in severe malnutrition.

Source: ctgov · Hamilton Health Sciences Corporation · NOT_YET_RECRUITING · 2026-05-27

URL: https://clinicaltrials.gov/study/NCT06593366

AI rationale (4/5, tier: preliminary): RCT of FMT intervention with microbiome and mechanistic endpoints; pilot stage but directly addresses engraftment dynamics and dysbiosis-disease links.

The purpose of this pilot randomized-controlled trial is to determine whether Fecal Microbiota Transplant (FMT) treatment demonstrates feasibility, acceptability, and prelinary effectiveness among patients with anorexia nervosa (AN). Specifically, the investigators aim to compare changes in weight, gut microbiome, urine, blood biomarkers and mood symptoms between participants receiving the FMT intervention and placebo.

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Published 2026-05-28 · Last kit-update 2026-05-28