Source: openalex · Xu Cui, Long-Yao Xu, Bing-Qian Yin, liu chen, Zheng Liang · World Journal of Hepatology · 2026-05-26
URL: https://doi.org/10.4254/wjh.v18.i5.115514
AI rationale (4/5, tier: emerging): Taxon-specific dysbiosis mechanism (Prevotellaceae) linked to metabolic phenotype via bile acid axis; mechanistic depth beyond descriptive ecology.
This letter commends on the study published in World Journal of Gastroenterology by Xu et al , which elucidated the mechanism by which distal bowel resection with terminal ileum preservation (DBRPI) improves hepatic gluconeogenesis via the Prevotellaceae NK3B31_group /7-ketolithocholic acid (7-KLCA)/farnesoid X receptor (FXR) axis. Using multiomics and functional assays, Xu et al identified this microbial–bile acid (BA) axis as central to the metabolic benefits of DBRPI, linking microbial enrichment (e.g. , Prevotellaceae NK3B31_group ) to increased 7-KLCA levels and FXR activation, thereby suppressing gluconeogenic gene expression. We highlight the novelty of this work in its focus on taxon-specific microbial and BA dynamics, which advances the understanding of postoperative glucose regulation. Additionally, we note its translational potential—targeting this axis via probiotics or 7-KLCA analogs—and raise several open questions, including causal validation of the microbial taxon, serum 7-KLCA dynamics, and glucagon-like-peptide-1/FXR interplay. Overall, this study bridges gut microbiota and BA crosstalk, offering actionable insights for the treatment of metabolic disease.