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All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.
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Evidence tier
6 articles of 156
Microbiota-derived butyrate inhibits colonic epithelial pyroptosis and mitigates DSS-induced colitis via interacting with aryl hydrocarbon receptor
SpeculationMucosa · Discovery · animal
**Source:** [pubmed](https://pubmed.ncbi.nlm.nih.gov/42177552/)
**Authors:** Zou F, Wu Z, Wang S, Xu M, Xia P
**Venue:** J Transl Med · 2026 May 23
**AI relevance (5/5):** Dire…
The omega-3 index as biomarker
EvidenceResolution biology · Markers · mechanism_review
**Summary**
The omega-3 index measures EPA + DHA as a percentage of total fatty acids in red blood cell phospholipids. It is the standardized, clinically-validated proxy for tissu…
Bile acids as signaling molecules — FXR and TGR5
HypothesisMucosa · Microbiome interface · mechanism_review
Bile acids are not just fat emulsifiers. They are signaling molecules.
The intestinal epithelium prominently expresses two key bile acid receptors — farnesoid X receptor (FXR) and…
The vagus nerve and the cholinergic anti-inflammatory pathway
HypothesisMucosa · Adjacent systems · mixed
The vagus nerve has anti-inflammatory properties through its afferents (activating HPA) and its efferents (the cholinergic anti-inflammatory pathway, CAP). The CAP inhibits pro-inf…
Trefoil factors (TFF1, TFF2, TFF3) — the active repair system
HypothesisMucosa · Architecture · mechanism_review
If SCFAs fuel the goblet cells, trefoil factors are the active repair signal. These small peptides are underappreciated and directly relevant.
Trefoil peptides play important role…
FMT — fecal microbiota transplantation
EvidenceMucosa · Interventions · mechanism_review
FMT has moved from experimental to standard treatment for specific indications.
FMT resolution of recurrent C. difficile infection: 81–95% across academic and private settings. FM…