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All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.
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Evidence tier
6 articles of 156
Specialized pro-resolving mediators (SPMs)
HypothesisResolution biology · Mediators · mechanism_review
**Summary**
SPMs are bioactive lipid metabolites derived from polyunsaturated fatty acids. They include four families: lipoxins (from arachidonic acid), E-series resolvins (from E…
The omega-3 index as biomarker
EvidenceResolution biology · Markers · mechanism_review
**Summary**
The omega-3 index measures EPA + DHA as a percentage of total fatty acids in red blood cell phospholipids. It is the standardized, clinically-validated proxy for tissu…
Resolution biology — SPMs (resolvins, protectins, maresins)
HypothesisMucosa · Adjacent systems · mechanism_review
**Summary**
Conceptually one of the most important paradigm shifts in inflammation research in the past 15 years, led by Charles Serhan at Harvard. Resolution of inflammation is n…
Butyrate and SCFAs — the central fuel
HypothesisMucosa · Microbiome interface · mechanism_review
Goblet cells and colonocytes run on butyrate as primary energy source. This is not incidental.
Butyrate serves as a key energy substrate for goblet cells producing MUC2 and protec…
Bile acids as signaling molecules — FXR and TGR5
HypothesisMucosa · Microbiome interface · mechanism_review
Bile acids are not just fat emulsifiers. They are signaling molecules.
The intestinal epithelium prominently expresses two key bile acid receptors — farnesoid X receptor (FXR) and…
Trefoil factors (TFF1, TFF2, TFF3) — the active repair system
HypothesisMucosa · Architecture · mechanism_review
If SCFAs fuel the goblet cells, trefoil factors are the active repair signal. These small peptides are underappreciated and directly relevant.
Trefoil peptides play important role…