Care Protocols
Evidence-based intervention pathways, AI-drafted from our published corpus and signed off by verified experts.
mucosa
Mucosal Barrier Restoration in UC Remission
Indication: Restore mucosal barrier (UC in remission)
This protocol addresses the active maintenance and restoration of intestinal mucosal barrier integrity in patients with ulcerative colitis in remission. The central evidence focuses on mucin architect…
mucosa
Mucosal Barrier Restoration Protocol — UC in Remission
Indication: Restore intestinal barrier (UC in remission)
This protocol synthesizes emerging evidence on restoring intestinal mucosal barrier integrity in UC patients in remission, targeting the mucus layer architecture, epithelial tight junctions, microbial…
mucosa
IBS-D Mucosal Management: Diet & Microbiome Protocol
Indication: IBS-D symptom management — diet and microbiome
This protocol addresses mucosal barrier integrity in IBS-D by targeting the mucin layer, goblet cell function, microbial balance, and epithelial repair through diet and microbiome-directed strategies.…
mucosa
SIBO Recurrence Prevention: Mucosal Integrity Protocol
Indication: SIBO recurrence prevention
SIBO recurrence is driven in part by mucosal vulnerability: a thinned or dysfunctional mucus layer, impaired antimicrobial peptide secretion, and ileocecal barrier instability that allows colonic bact…
microbiome
Dysbiosis-Driven Low-Grade Systemic Inflammation: Microbiome Protocol
Indication: Dysbiosis-driven low-grade systemic inflammation
This protocol addresses dysbiosis-driven low-grade systemic inflammation by targeting the gut microbiome through diet, supplementation, and lifestyle modifications. The evidence base spans RCTs, syste…
microbiome
Post-Antibiotic Microbiome Restoration Protocol
Indication: Post-antibiotic microbiome restoration
This protocol synthesises current evidence on restoring gut microbiome diversity and colonisation resistance following antibiotic exposure, a period characterised by loss of keystone taxa, expansion o…
sleep
Sleep Improvement Protocol for Mid-Life Adults
Indication: Improve insomnia in mid-life adults
This protocol synthesises current emerging and preliminary evidence to address insomnia in mid-life adults through circadian biology, light exposure, dietary timing, and neuromodulatory mechanisms. Ce…
sleep
OSA Lifestyle Adjuncts: Evidence-Based Care Protocol
Indication: Manage obstructive sleep apnea — lifestyle adjuncts
This protocol synthesises available evidence for lifestyle-based adjunctive strategies in the management of obstructive sleep apnea (OSA), targeting modifiable pathophysiological drivers including cir…
sleep
Shift-Work Circadian Recovery Protocol
Indication: Shift-work circadian recovery protocol
Shift workers experience chronic circadian misalignment that disrupts the molecular clock machinery (CLOCK-BMAL1), suppresses melatonin secretion, elevates oxidative stress, and impairs glymphatic was…
stress
Chronic Stress Recovery: HPA-Axis Support Protocol
Indication: Chronic stress recovery — HPA-axis support
This protocol synthesizes current emerging and preliminary evidence for supporting HPA-axis recovery in chronic stress, targeting autonomic nervous system rebalancing, allostatic load reduction, and g…
stress
Burnout Prevention & Recovery: Stress Protocol
Indication: Burnout prevention and recovery
This protocol synthesises emerging evidence on autonomic nervous system regulation, HPA-axis biomarkers, and allostatic load reduction as core mechanistic targets in burnout prevention and recovery. E…
stress
Anxiety with Autonomic Dysregulation: Stress-Focused Care Protocol
Indication: Anxiety with autonomic dysregulation
This protocol addresses anxiety with autonomic dysregulation by targeting the interplay between HPA-axis hyperactivity, reduced vagal tone, and allostatic load accumulation. Evidence from psychophysio…
mitochondria
Mitochondrial Dysfunction in Chronic Fatigue: Evidence-Based Protocol
Indication: Mitochondrial dysfunction in chronic fatigue
This protocol addresses the mechanistic drivers of mitochondrial dysfunction underlying chronic fatigue, including impaired mitophagy, NAD⁺ depletion, ROS accumulation, and dysregulated mitochondrial …
mitochondria
Metabolic Syndrome: Mitochondrial-Supportive Lifestyle Protocol
Indication: Metabolic syndrome — mitochondrial-supportive lifestyle
This protocol synthesizes emerging and preliminary evidence on mitochondrial-supportive lifestyle strategies for individuals with metabolic syndrome, targeting core mechanisms including mitophagy, NAD…
autophagy
Autophagy Activation Protocol for Healthy Aging
Indication: Autophagy activation for healthy aging
This protocol synthesizes emerging and preliminary evidence on lifestyle, nutritional, and pharmacological strategies reported to activate or support autophagy flux in the context of healthy aging. Ce…
autophagy
Time-Restricted Eating for Metabolic Health: Autophagy Protocol
Indication: Time-restricted eating for metabolic health
This protocol synthesises emerging evidence on how time-restricted eating (TRE) modulates autophagy flux through AMPK/mTOR signalling to support metabolic health, particularly in the context of type 2…
chronic-inflammation
Anti-Inflammatory Lifestyle Protocol for Low-Grade Chronic Inflammation
Indication: Low-grade chronic inflammation — anti-inflammatory lifestyle
This protocol synthesises current evidence for managing low-grade chronic inflammation through lifestyle-based interventions targeting key mechanistic pathways including the NLRP3 inflammasome, oxidat…
chronic-inflammation
Cardiovascular Risk Reduction via Chronic Inflammation Control
Indication: Cardiovascular risk reduction via inflammation control
This protocol synthesizes emerging and preliminary evidence for reducing cardiovascular risk through targeted control of chronic low-grade inflammation, with a focus on the NLRP3 inflammasome pathway,…
resolution
SPM-Focused Inflammation Resolution Protocol
Indication: Specialized pro-resolving mediators in inflammation resolution
This protocol addresses the active, mediator-driven phase of inflammation resolution, centered on specialized pro-resolving mediators (SPMs) derived from omega-3 and omega-6 polyunsaturated fatty acid…
resolution
Post-Infection Inflammation Resolution Support Protocol
Indication: Post-infection inflammation resolution support
This protocol synthesizes evidence on the active resolution phase of inflammation following infection, focusing on interventions that support specialized pro-resolving mediator (SPM) biosynthesis and …
chronic-inflammation
Polyphenol-Rich Diet Protocol for Chronic Inflammation Management
Indication: Polyphenol-rich diet for systemic health
This protocol synthesizes available evidence for dietary and lifestyle strategies targeting chronic low-grade inflammation, with a focus on NLRP3 inflammasome modulation, oxidative stress reduction, a…
mitochondria
Sarcopenia Prevention: Mitochondria-Targeted Nutrition & Exercise Protocol
Indication: Sarcopenia prevention through nutrition and exercise
This protocol synthesizes emerging and preliminary evidence on mitochondrial mechanisms—including mitophagy, NAD⁺ metabolism, PGC-1α/SirT1 signalling, and mitochondrial biogenesis—relevant to sarcopen…
chronic-inflammation
Neuroinflammation Reduction via Chronic Inflammation Pathways
Indication: Neuroinflammation reduction strategies
This protocol synthesizes emerging and preliminary evidence targeting key chronic neuroinflammatory mechanisms, including the NLRP3 inflammasome, ROS/TXNIP axis, T-cell senescence, and systemic cytoki…