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All published Bionoia articles. Filter by topic, evidence tier, study type, or tag.

Topic
Autophagy & cellular renewal 16Chronic inflammation 5Microbiome ecology 21Mitochondrial biology 22Mucosa 55Resolution biology 4Sleep biology 18Stress biology 15
Evidence tier
Evidence 3Hypothesis 65Speculation 30
Study type
Human observational 1Mixed 2Animal 1Mechanism review 17
Tags
mechanism 19barrier 17microbiome 14inflammation 14marker 14intervention 6supplement 6technique 3resolution 2ernæring 2omega-3 2goblet cells 2dysbiosis 2sepsis 2eicosanoids 1
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4 articles of 156

Resolution biology — SPMs (resolvins, protectins, maresins)
Hypothesis
Mucosa · Adjacent systems · mechanism_review
**Summary** Conceptually one of the most important paradigm shifts in inflammation research in the past 15 years, led by Charles Serhan at Harvard. Resolution of inflammation is n…
Butyrate and SCFAs — the central fuel
Hypothesis
Mucosa · Microbiome interface · mechanism_review
Goblet cells and colonocytes run on butyrate as primary energy source. This is not incidental. Butyrate serves as a key energy substrate for goblet cells producing MUC2 and protec…
Bile acids as signaling molecules — FXR and TGR5
Hypothesis
Mucosa · Microbiome interface · mechanism_review
Bile acids are not just fat emulsifiers. They are signaling molecules. The intestinal epithelium prominently expresses two key bile acid receptors — farnesoid X receptor (FXR) and…
Trefoil factors (TFF1, TFF2, TFF3) — the active repair system
Hypothesis
Mucosa · Architecture · mechanism_review
If SCFAs fuel the goblet cells, trefoil factors are the active repair signal. These small peptides are underappreciated and directly relevant. Trefoil peptides play important role…