Where life meets thought.
A living research corpus for clinicians, specialists, and scientists. Every article carries a clear evidence label — so you know at a glance whether you are reading evidence, a hypothesis, speculation, or established practice.
Ligature-induced periodontitis in mice potentially accelerates CD4+ T-cell senescence and exacerbates rheumatoid arthritis
Introduction Aging impairs immunity, sustains chronic inflammation, and enhances autoimmunity–a process termed “immunosenescence” that contributes to the pathogenesis of type 2 diabetes and rheumatoid arthritis (RA). Post-pubertal thymic involution depletes naïve T-cell pool, promoting the emergence of senescent CD4 + T cells. To maintain T-cell homeostasis, these cells…
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30 articles tagged Speculation, sorted by date
Effect of methotrexate on endothelial function in psoriasis patients
INTRODUCTION: Psoriasis is a chronic immune-mediated inflammatory dermatosis associated with systemic comorbidities, including metabolic disorders, atherosclerosis, and increased…
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Dexmedetomidine attenuates LPS-induced acute lung injury via activation of mitochondrial autophagy
This study aimed to examine the impact of Dex on ALI and clarify the mechanisms, particularly regarding mitophagy. The assignment of male Sprague–Dawley rats was random, with rats…
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Impact of aldehyde dehydrogenase 2 deficiency on tissue-specific mitochondrial metabolism in aging mice
Age-related diseases arise from prolonged exposure to genetic and/or environmental factors, ultimately leading to cumulative and irreversible degeneration of tissues and the…
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Fecal Microbiota Transplant for Anorexia Nervosa
The purpose of this pilot randomized-controlled trial is to determine whether Fecal Microbiota Transplant (FMT) treatment demonstrates feasibility, acceptability, and prelinary…
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Anti-inflammatory and gut microbiota-modulating effects of a novel mannan from Scilla scilloides on DSS-induced colitis in mice
Scilla scilloides is a traditional plant with medicinal and nutritional value, known for its diverse biological activities. This study aimed to identify the structure of a novel…
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Emapunil attenuates ulcerative colitis by suppressing Z-DNA binding protein 1 driven pyroptosis and pro-inflammatory polarization in macrophages
Background The pathogenesis of ulcerative colitis (UC) remains incompletely understood, and effective therapeutic targets are still lacking in clinical practice. Macrophage…
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Eubacterium rectale Mitigates Inflammatory Bowel Disease via Modulation of Glutamine Metabolism Through the GLS2 and NF-κB Pathway
Inflammatory Bowel Disease (IBD) is a chronic inflammatory intestinal disorder with complex etiology, closely associated with gut microbiota dysbiosis. This study demonstrates…
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Low-dimensional population dynamics in the brainstem gate REM sleep
Rapid-eye-movement (REM) sleep is generated in the brainstem, but the brainstem population dynamics that drive transitions to REM sleep remain largely unknown. Here, combining…
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Semaglutide targets the Isg15-FUNDC1 axis: suppressing IFN-β overactivation and attenuating blood-brain barrier injury in diabetic intracerebral hemorrhage
<h4>Background</h4>Intracerebral hemorrhage complicated by diabetes mellitus (DM-ICH) is characterized by severe secondary injury of the blood-brain barrier (BBB) and poor…
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