Resolution biology
Inflammation as a two-phase process
Resolution biology reframes inflammation as a two-phase active process: initiation followed by SPM-driven resolution. When the resolution phase fails (often due to omega-3 deficiency), inflammation persists — a mechanism behind many chronic conditions. This topic curates the…
Comprehensive analysis of efferocytosis-related genes in diagnosis and immune infiltration in atherosclerosis: based on bulk and single-cell RNA sequencing data
Background Atherosclerosis (AS) is a widespread cardiovascular disorder that constitutes a major contributor to global morbidity and mortality, thereby imposing significant economic burdens on healthcare systems worldwide. Efferocytosis, the phagocytic removal of apoptotic cells, serves as a fundamental mechanism for maintaining tissue homeostasis during normal physiological…
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3 articles in Resolution biology tagged Hypothesis, sorted by date
Resolution as an active process
Summary For decades inflammation was understood as a single process that simply "wore off" once the trigger was removed. Resolution was passive — what happened when nothing more…
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Specialized pro-resolving mediators (SPMs)
Summary SPMs are bioactive lipid metabolites derived from polyunsaturated fatty acids. They include four families: lipoxins (from arachidonic acid), E-series resolvins (from EPA),…
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